Drug discovery strategies to outer membrane targets in Gram-negative pathogens

被引：19
作者：
Brown, Dean G. [1 ]
机构：
[1] AstraZeneca Neurosci, Innovat Med & Early Dev Unit, 141 Portland St,10th Floor, Cambridge, MA 02139 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2016年 / 24卷 / 24期
关键词：
Antibacterial; Gram-negative; Outer membrane; Lipid A; Lipopolysaccharide; SPHEROPLAST-FORMING ACTIVITY; ESCHERICHIA-COLI; SIGNAL PEPTIDASE; STRUCTURAL BASIS; POLYMYXIN-B; BACTERIAL LIPOPOLYSACCHARIDES; NATURAL-PRODUCTS; MOLECULAR-BASIS; ANTIBIOTICS; LIPOPROTEIN;
D O I：
10.1016/j.bmc.2016.05.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review will cover selected recent examples of drug discovery strategies which target the outer membrane (OM) of Gram-negative bacteria either by disruption of outer membrane function or by inhibition of essential gene products necessary for outer membrane assembly. Significant advances in pathway elucidation, structural biology and molecular inhibitor designs have created new opportunities for drug discovery within this target-class space. (C) 2016 Elsevier Ltd. All rights reserved.
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收藏
页码：6320 / 6331
页数：12
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