The Spindle Assembly Checkpoint

被引：589

作者：

Lara-Gonzalez, Pablo ^{[1
]}

Westhorpe, Frederick G. ^{[1
]}

Taylor, Stephen S. ^{[1
]}

机构：

[1] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England

来源：

CURRENT BIOLOGY | 2012年 / 22卷 / 22期

基金：

英国惠康基金;

关键词：

ANAPHASE-PROMOTING COMPLEX; VERTEBRATE SOMATIC-CELLS; MITOTIC CHECKPOINT; KINETOCHORE LOCALIZATION; CHROMOSOME SEGREGATION; CENTROMERIC COHESION; MICROTUBULE-BINDING; STRUCTURAL-ANALYSIS; MAD2; ACTIVATION; KINASE-ACTIVITY;

D O I：

10.1016/j.cub.2012.10.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome stability by delaying cell division until accurate chromosome segregation can be guaranteed. Accuracy requires that chromosomes become correctly attached to the microtubule spindle apparatus via their kinetochores. When not correctly attached to the spindle, kinetochores activate the spindle assembly checkpoint network, which in turn blocks cell cycle progression. Once all kinetochores become stably attached to the spindle, the checkpoint is inactivated, which alleviates the cell cycle block and thus allows chromosome segregation and cell division to proceed. Here we review recent progress in our understanding of how the checkpoint signal is generated, how it blocks cell cycle progression and how it is extinguished.

引用

页码：R966 / R980

页数：15

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