Association between a polymorphism in the promoter of a glutamate receptor subunit gene (GRIN2A) and alcoholism

被引：25
作者：
Domart, Marie-Charlotte [1 ]
Benyamina, Amine [2 ,3 ]
Lemoine, Antoinette [1 ]
Bourgain, Catherine [3 ]
Blecha, Lisa [2 ,3 ]
Debuire, Brigitte [1 ]
Reynaud, Michel [2 ,3 ]
Saffroy, Raphael [1 ]
机构：
[1] Univ Paris 11, Hop Paul Brousse, AP HP, INSERM,Lab Biochim & Biol Mol,IFR89,U1004, Villejuif, France
[2] Hop Paul Brousse, AP HP, Serv Addictol, F-94800 Villejuif, France
[3] INSERM, U669, Villejuif, France
来源：
ADDICTION BIOLOGY | 2012年 / 17卷 / 04期
关键词：
Addiction; alcohol-dependence; glutamate; GRIN2A; NMDA; (GT)n repeat; SCHIZOPHRENIA; DEPENDENCE; BEHAVIOR; MTHFR;
D O I：
10.1111/j.1369-1600.2011.00321.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A variable (GT)n repeat in the 5'-regulatory region of N-methyl-D-aspartate GRIN2A subtype has recently been identified and associated with psychiatric disorders. In this study, we examined the association of this polymorphism with alcohol dependence. Subjectcontrol analysis included 206 alcohol-dependent and 168 control subjects. Average observed repeat numbers and genotype distributions were significantly different (P-value = 0.001) in alcohol-dependent subjects versus control subjects. Short alleles were significantly less frequent among alcohol-dependent subjects (odds ratio = 0.58, P-value = 7 x 10(-4)). These results could be replicated in an independent sample of 116 alcohol-dependent subjects. For the first time, a significant association was identified between this polymorphism and alcoholism.
引用
收藏
页码：783 / 785
页数：3
相关论文
共 50 条
  • [31] No association between the ionotropic glutamate receptor kainate 3 gene Ser310ala polymorphism and schizophrenia
    Lai, IC
    Liou, YJ
    Chen, JY
    Wang, YC
    [J]. NEUROPSYCHOBIOLOGY, 2005, 51 (04) : 211 - 213
  • [32] Protective influences of N-acetylcysteine against alcohol abstinence-induced depression by regulating biochemical and GRIN2A, GRIN2B gene expression of NMDA receptor signaling pathway in rats
    Yawalkar, Rutuja
    Changotra, Harish
    Gupta, Girdhari Lal
    [J]. NEUROCHEMISTRY INTERNATIONAL, 2018, 118 : 73 - 81
  • [33] Genetic analysis of a functional GRIN2A promoter (GT)n repeat in bipolar disorder pedigrees in humans
    Itokawa, M
    Yamada, K
    Iwayama-Shigeno, Y
    Ishitsuka, Y
    Detera-Wadleigh, S
    Yoshikawa, T
    [J]. NEUROSCIENCE LETTERS, 2003, 345 (01) : 53 - 56
  • [34] Disease-Associated Variants in GRIN1,, GRIN2A and GRIN2B genes: Insights into NMDA Receptor Structure, Function, and Pathophysiology
    Korinek, Miloslav
    Serra, Miriam Candelas
    Rahman, Fatma Elzahraa S. Abdel
    Dobrovolski, Mark
    Kuchtiak, Viktor
    Abramova, Vera
    Fili, Klevinda
    Tomovic, Eni
    Krausova, Barbora Hrcka
    Krusek, Jan
    Cerny, Jiri
    Vyklicky, Ladislav
    Balik, Ales
    Smejkalova, Tereza
    [J]. PHYSIOLOGICAL RESEARCH, 2024, 73 : S413 - S434
  • [35] An association study of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B) in schizophrenia with universal DNA microarray
    Qin, SY
    Zhao, X
    Pan, YX
    Liu, JH
    Feng, GY
    Fu, JC
    Bao, JY
    Zhang, ZZ
    He, L
    [J]. EUROPEAN JOURNAL OF HUMAN GENETICS, 2005, 13 (07) : 807 - 814
  • [36] Association between NMDA receptor subunit 2b gene polymorphism and Alzheimer's disease in Chinese Han population in Shanghai
    Chen, Chao
    Li, Xia
    Wang, Tao
    Wang, Hai-Hong
    Fu, Yi
    Zhang, Lei
    Xiao, Shi-Fu
    [J]. NEUROSCIENCE BULLETIN, 2010, 26 (05) : 395 - 400
  • [37] An association study of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B) in schizophrenia with universal DNA microarray
    Shengying Qin
    Xu Zhao
    Yuxi Pan
    Jianhua Liu
    Guoyin Feng
    Jingchun Fu
    Jiying Bao
    Zhizhou Zhang
    Lin He
    [J]. European Journal of Human Genetics, 2005, 13 : 807 - 814
  • [38] Association analysis between the C-1291G polymorphism in the promoter region of the adrenergic α2A receptor gene and polydipsia in schizophrenia
    Yamaguchi, Wakana
    Shinkai, Takahiro
    Inoue, Yoshiaki
    Utsunomiya, Kensuke
    Sakata, Shinichi
    Fukunaka, Yuko
    Yamada, Kenji
    Chen, Hsin-I
    Hwang, Rudi
    Ohmori, Osamu
    Nakamura, Jun
    [J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2009, 33 (03) : 499 - 502
  • [39] Dopamine D2 receptor promoter polymorphism:: no association with schizophrenia
    Tallerico, T
    Ulpian, C
    Liu, ISC
    [J]. PSYCHIATRY RESEARCH, 1999, 85 (02) : 215 - 219
  • [40] Evidence of association between smoking and α7 nicotinic receptor subunit gene in schizophrenia patients
    De Luca, V
    Wong, AHC
    Muller, DJ
    Wong, GWH
    Tyndale, RF
    Kennedy, JL
    [J]. NEUROPSYCHOPHARMACOLOGY, 2004, 29 (08) : 1522 - 1526
12345