Germacrane-Type Sesquiterpenoids with Antiproliferative Activities from Eupatorium chinense

被引：24

作者：

Yu, Xiaoqin ^{[1
,2
]}

Zhang, Jugging ^{[1
]}

Tian, Li ^{[1
]}

Guo, Zhiyong ^{[1
]}

Liu, Chengxiong ^{[1
]}

Chen, Jianfeng ^{[1
]}

Ebrahim, Weaam ^{[2
,3
]}

Liu, Zhen ^{[2
]}

Proksch, Peter ^{[2
]}

Zou, Kun ^{[1
]}

机构：

[1] China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China

[2] Heinrich Heine Univ Duesseldorf, Inst Pharmaceut Biol & Biotechnol, D-40225 Dusseldorf, Germany

[3] Mansoura Univ, Fac Pharm, Dept Pharmacognosy, Mansoura 35516, Egypt

来源：

JOURNAL OF NATURAL PRODUCTS | 2018年 / 81卷 / 01期

关键词：

ABSOLUTE-CONFIGURATION; PLANTS; CELLS; L;

D O I：

10.1021/acs.jnatprod.7b00693

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ten new germacrane-type sesquiterpenoids (1-10) were isolated from a whole plant extract of Eupatorium chinense. The structures were elucidated by analysis of their NMR and MS data as well as by comparison with literature values. The absolute configuration of eupachinsin A (1) was determined by single-crystal X-ray diffraction analysis. Compounds 3 and 4 exhibited cytotoxicity against a human breast cancer cell line (MDA-MB-231), with IC50 values of 0.8 and 3.4 mu M, respectively. In addition, compounds 3-5 showed cytotoxicity against the human hepatocellular carcinoma cell line (HepG(2)), with IC50 values ranging from 3.6 to 7.6 mu M.

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收藏

页码：85 / 91

页数：7

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