Synthesis and biological activity of novel amino acid-(N′-benzoyl) hydrazide and amino acid-(N′-nicotinoyl) hydrazide derivatives.

被引:50
作者
Khattab, SN [1 ]
机构
[1] Univ Alexandria, Fac Sci, Dept Chem, Alexandria 21321, Egypt
关键词
benzoic acid hydrazide; nicotinic acid hydrazide; amino acid hydrazide derivatives; Copper and Cadmium complexes; antimicrobial agents;
D O I
10.3390/10091218
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The coupling reaction of benzoic acid and nicotinic acid hydrazides with N-protected L-amino acids including valine, leucine, phenylalanine, glutamic acid and tyrosine is reported. The target compounds, N-Boc-amino acid-(N'-benzoyl)- and N-Boc-amino acid-(N'-nicotinoyl) hydrazides 5a-5e and 6a-6e were prepared in very high yields and purity using N-[(dimethylamino)-1H-1,2,3-triazolo[4,5-b]pyridin-1-ylmethylene]-N-methyl-methanaminium hexafluorophosphate N-oxide (HATU) as coupling reagent. The antimicrobial activity of the Cu and Cd complexes of the designed compounds was tested. The products were deprotected affording the corresponding amino acid-(N'-benzoyl) hydrazide hydrochloride salts (7a-7e) and amino acid-(N'-nicotinoyl) hydrazide hydrochloride salts (8a-8e). These compounds and their Cu and Cd complexes were also tested for their antimicrobial activity. Several compounds showed comparable activity to that of ampicillin against S. aureus and E. coli.
引用
收藏
页码:1218 / 1228
页数:11
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