Hippocampal subfields predict positive symptoms in schizophrenia: First evidence from brain morphometry

被引：68

作者：

Kuehn, S. ^{[1
,2
]}

Musso, F. ^{[3
]}

Mobascher, A. ^{[4
,5
]}

Warbrick, T. ^{[5
]}

Winterer, G. ^{[5
,6
]}

Gallinat, J. ^{[2
]}

机构：

[1] Univ Ghent, Ghent Inst Funct & Metab Imaging, Dept Expt Psychol, Fac Psychol & Educ Sci, B-9000 Ghent, Belgium

[2] Charite, St Hedwig Krankenhaus, Clin Psychiat & Psychotherapy, D-13353 Berlin, Germany

[3] Univ Dusseldorf, Dept Psychiat, Dusseldorf, Germany

[4] Johannes Gutenberg Univ Mainz, Dept Psychiat, D-6500 Mainz, Germany

[5] Helmholtz Res Ctr Julich, Inst Neurosci & Med, Julich, Germany

[6] Univ Cologne, Cologne Ctr Genom, D-50931 Cologne, Germany

来源：

TRANSLATIONAL PSYCHIATRY | 2012年 / 2卷

关键词：

CA1; CA2/3; FreeSurfer; hippocampus; schizophrenia; volumetry; MRI;

D O I：

10.1038/tp.2012.51

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Alterations of hippocampal anatomy have been reported consistently in schizophrenia. Within the present study, we used FreeSurfer to determine hippocampal subfield volumes in 21 schizophrenic patients. A negative correlation between PANSS-positive symptom score and bilateral hippocampal subfield CA2/3 as well as CA1 volume was found on high-resolution magnetic resonance images. Our observation opens the gate for advanced investigation of the commonly reported hippocampal abnormalities in schizophrenia in terms of specific subfields. Translational Psychiatry (2012) 2, e127; doi:10.1038/tp.2012.51; published online 12 June 2012

引用

页码：e127 / e127

页数：2

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