Hippocampal subfields predict positive symptoms in schizophrenia: First evidence from brain morphometry

被引：68
|
作者：
Kuehn, S. [1 ,2 ]
Musso, F. [3 ]
Mobascher, A. [4 ,5 ]
Warbrick, T. [5 ]
Winterer, G. [5 ,6 ]
Gallinat, J. [2 ]
机构：
[1] Univ Ghent, Ghent Inst Funct & Metab Imaging, Dept Expt Psychol, Fac Psychol & Educ Sci, B-9000 Ghent, Belgium
[2] Charite, St Hedwig Krankenhaus, Clin Psychiat & Psychotherapy, D-13353 Berlin, Germany
[3] Univ Dusseldorf, Dept Psychiat, Dusseldorf, Germany
[4] Johannes Gutenberg Univ Mainz, Dept Psychiat, D-6500 Mainz, Germany
[5] Helmholtz Res Ctr Julich, Inst Neurosci & Med, Julich, Germany
[6] Univ Cologne, Cologne Ctr Genom, D-50931 Cologne, Germany
来源：
TRANSLATIONAL PSYCHIATRY | 2012年 / 2卷
关键词：
CA1; CA2/3; FreeSurfer; hippocampus; schizophrenia; volumetry; MRI;
D O I：
10.1038/tp.2012.51
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Alterations of hippocampal anatomy have been reported consistently in schizophrenia. Within the present study, we used FreeSurfer to determine hippocampal subfield volumes in 21 schizophrenic patients. A negative correlation between PANSS-positive symptom score and bilateral hippocampal subfield CA2/3 as well as CA1 volume was found on high-resolution magnetic resonance images. Our observation opens the gate for advanced investigation of the commonly reported hippocampal abnormalities in schizophrenia in terms of specific subfields. Translational Psychiatry (2012) 2, e127; doi:10.1038/tp.2012.51; published online 12 June 2012
引用
收藏
页码：e127 / e127
页数：2
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