Evaluation of anterior segment parameters with two anterior segment optical coherence tomography systems: Visante and Casia, in primary angle closure disease

To determine the comparability of anterior chamber biometric measurements in primary angle closure disease (PACD) patients using two commercially available anterior segment optical coherence tomography machines (ASOCT): Visante and Casia. Methods: This was a cross-sectional observational study, which included clinically, diagnosed cases of PACD. Anterior segment biometric measurements were done using Casia and Visante ASOCT. Parameters studied were central corneal thickness (CCT), anterior chamber depth (ACD), nasal (N) and temporal (1) angle opening distance at 500 mu m (AOD500) and 750 mu m (AOD750), and N and T trabecular iris space area at 500 mu m (TISA500) and 750 mu m (TIM 750). Results. Total 36 PACD patients (72 eyes) with average age of 59.48 +/- 7.95 years were recruited, out of which 25 were females (69.44%) and 11 males (30.56%). The mean measurements of CCT, ACD, AOD500, and TISA on Casia and Visante machines were 522.5 +/- 34.75 mu m and 539.55 +/- 29.56 mu m (P = 0.00); ACD- 2.144 +/- 0.38 mu m and 2.133 +/- 0.39 mu m (P = 0.487); AOD500-0.27 +/- 0.16 mu m and 0.21 +/- 0.10 mu m (P = 0.04); and TISA500-0.100 +/- 0.07 mu m and 0.063 +/- 0.03 mu m (P = 0.00), respectively. A statistically significant difference was noted in CCT, N and T AOD, and TISA. A good corelation for ACD and CCT (ACD = 0.9816 and CCT = 0.772) only were noted between the two machines. The Bland-Altman plot analysis of different parameters between two machines has revealed good agreement of measurement of ACD and CCT but poor agreement for rest of the parameters. Conclusion: It is advisable not use the two machines interchangeably because of the wide limits of agreement and poor correlation of angle measurement values of Casia and Visante ASOCT.