Heart rate and rate control. Prognostic value in cardiovascular diseases

被引：0

作者：

Custodis, F. ^{[1
]}

Reil, J. -C. ^{[1
]}

Laufs, U. ^{[1
]}

Boehm, M. ^{[1
]}

机构：

[1] Univ Klinikum Saarlandes, Klin Innere Med Kardiol Angiol & Internist Intens, D-66421 Homburg, Germany

来源：

INTERNIST | 2012年 / 53卷 / 01期

关键词：

Resting heart rate; Risk marker; Heart failure; Coronary artery disease; I(f) channel inhibition; PLACEBO-CONTROLLED TRIAL; CORONARY-ARTERY-DISEASE; I-F INHIBITOR; RATE REDUCTION; ENDOTHELIAL FUNCTION; STABLE ANGINA; DOUBLE-BLIND; RISK-FACTOR; IVABRADINE; FAILURE;

D O I：

10.1007/s00108-011-2887-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Resting heart rate represents a cardiovascular risk indicator and an important target of therapy in chronic heart failure and potentially in coronary artery disease. Clinical and experimental evidence suggests that sustained elevation of heart rate - independent of the underlying trigger - plays a causal role in the pathogenesis of vascular disease. Results of the SHIFT trial support the importance of heart-rate reduction with ivabradine for improvement of clinical outcomes in heart failure and confirm the role of heart rate as a risk factor for patients with severe left ventricular dysfunction. Results of the BEAUTIFUL trial show that patients with ischemic heart disease and a heart rate above 70 bpm exhibit an adverse prognosis concerning coronary events.

引用

页码：6 / +

页数：7

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