Cerebrospinal fluid pentraxin 3 and CD40 ligand in anti-N-menthyl-D-aspartate receptor encephalitis

被引：14

作者：

Liu, Baozhu ^{[1
]}

Ai, Peiying ^{[1
]}

Zheng, Dong ^{[2
]}

Jiang, Ying ^{[3
]}

Liu, Xiaojia ^{[1
]}

Pan, Suyue ^{[1
]}

Wang, Honghao ^{[1
]}

机构：

[1] Southern Med Univ, Nanfang Hosp, Dept Neurol, 1838 North Guangzhou Ave, Guangzhou 510515, Guangdong, Peoples R China

[2] Guangzhou Brain Hosp, Dept Neurol, Guangzhou, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Hosp Affiliated 3, Dept Neurol, Guangzhou, Guangdong, Peoples R China

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2018年 / 315卷

基金：

中国国家自然科学基金;

关键词：

Anti-NMDAR encephalitis; Inflammation; Cytokine; Cerebrospinal fluid; PTX3; CD40L; MULTIPLE-SCLEROSIS; DISEASE; PTX3; ACTIVATION; EXPRESSION; DISORDERS; MICROGLIA;

D O I：

10.1016/j.jneuroim.2017.11.016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder of the central nervous system whose pathogenesis involves interleukin (IL)-6 and IL-17A. We examined the correlations between CSF concentrations of the acute-phase protein pentraxin 3 (PTX3), the chronic inflammatory mediator CD40L, IL-6, and IL-17A in anti-NMDAR encephalitis, and the impact on clinical outcome. PTX3, CD40L, IL-6, and IL-17A were significantly higher in the CSF of patients with anti-NMDAR encephalitis than in controls. Within the former, PTX3 levels correlated positively with IL-6 and the mRS, and CD40L levels with IL-17A and the mRS. Higher PTX3 and CD40L levels may reflect the underlying neuroinflammation.

引用

页码：40 / 44

页数：5

共 38 条

[31] Pentraxin 3 is an anti-inflammatory protein associated with lipid-induced interleukin 10 in vitro
Slusher, Aaron L.
Mischo, Amanda B.
Acevedo, Edmund O.
[J]. CYTOKINE, 2016, 86 : 36 - 40
[32] Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study
Titulaer, Maarten J.
McCracken, Lindsey
Gabilondo, Inigo
Armangue, Thais
Glaser, Carol
Iizuka, Takahiro
Honig, Lawrence S.
Benseler, Susanne M.
Kawachi, Izumi
Martinez-Hernandez, Eugenia
Aguilar, Esther
Gresa-Arribas, Nuria
Ryan-Florance, Nicole
Torrents, Abiguei
Saiz, Albert
Rosenfeld, Myrna R.
Balice-Gordon, Rita
Graus, Francesc
Dalmau, Josep
[J]. LANCET NEUROLOGY, 2013, 12 (02) : 157 - 165
[33] Platelets and cytokines in concert with endothelial activation in patients with peripheral arterial occlusive disease
Tsakiris, DA
Tschöpl, M
Wolf, F
Labs, KH
Jäger, KA
Marbet, GA
[J]. BLOOD COAGULATION & FIBRINOLYSIS, 2000, 11 (02) : 165 - 173
[34] Evidence for antibody-mediated pathogenesis in anti-NMDAR encephalitis associated with ovarian teratoma
Tuezuen, Erdem
Zhou, Lei
Baehring, Joachim M.
Bannykh, Serguei
Rosenfeld, Myrna R.
Dalmau, Josep
[J]. ACTA NEUROPATHOLOGICA, 2009, 118 (06) : 737 - 743
[35] Cytokine and chemokine profiles in neuromyelitis optica: significance of interleukin-6
Uzawa, Akiyuki
Mori, Masahiro
Arai, Kimihito
Sato, Yasunori
Hayakawa, Sei
Masuda, Saeko
Taniguchi, Junko
Kuwabara, Satoshi
[J]. MULTIPLE SCLEROSIS JOURNAL, 2010, 16 (12) : 1443 - 1452
[36] Anti-NMDA-receptor encephalitis: a cause of psychiatric, seizure, and movement disorders in young adults
Vincent, Angela
Bien, Christian G.
[J]. LANCET NEUROLOGY, 2008, 7 (12) : 1074 - 1075
[37] Anti-NMDA-receptor encephalitis: A severe, multistage, treatable disorder presenting with psychosis
Wandinger, Klaus-Peter
Saschenbrecker, Sandra
Stoecker, Winfried
Dalmau, Josep
[J]. JOURNAL OF NEUROIMMUNOLOGY, 2011, 231 (1-2) : 86 - 91
[38] Plasma Pentraxin 3, but not High-sensitivity C-reactive Protein, is a Useful Inflammatory Biomarker for Predicting Cognitive Impairment in Elderly Hypertensive Patients
Yano, Yuichiro
Matsuda, Shuntaro
Hatakeyama, Kinta
Sato, Yuichiro
Imamura, Takuroh
Shimada, Kazuyuki
Kodama, Tatuhiko
Kario, Kazuomi
Asada, Yujiro
[J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2010, 65 (05): : 547 - 552

← 1 2 3 4 →