Cerebrospinal fluid pentraxin 3 and CD40 ligand in anti-N-menthyl-D-aspartate receptor encephalitis

被引：14

作者：

Liu, Baozhu ^{[1
]}

Ai, Peiying ^{[1
]}

Zheng, Dong ^{[2
]}

Jiang, Ying ^{[3
]}

Liu, Xiaojia ^{[1
]}

Pan, Suyue ^{[1
]}

Wang, Honghao ^{[1
]}

机构：

[1] Southern Med Univ, Nanfang Hosp, Dept Neurol, 1838 North Guangzhou Ave, Guangzhou 510515, Guangdong, Peoples R China

[2] Guangzhou Brain Hosp, Dept Neurol, Guangzhou, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Hosp Affiliated 3, Dept Neurol, Guangzhou, Guangdong, Peoples R China

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2018年 / 315卷

基金：

中国国家自然科学基金;

关键词：

Anti-NMDAR encephalitis; Inflammation; Cytokine; Cerebrospinal fluid; PTX3; CD40L; MULTIPLE-SCLEROSIS; DISEASE; PTX3; ACTIVATION; EXPRESSION; DISORDERS; MICROGLIA;

D O I：

10.1016/j.jneuroim.2017.11.016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder of the central nervous system whose pathogenesis involves interleukin (IL)-6 and IL-17A. We examined the correlations between CSF concentrations of the acute-phase protein pentraxin 3 (PTX3), the chronic inflammatory mediator CD40L, IL-6, and IL-17A in anti-NMDAR encephalitis, and the impact on clinical outcome. PTX3, CD40L, IL-6, and IL-17A were significantly higher in the CSF of patients with anti-NMDAR encephalitis than in controls. Within the former, PTX3 levels correlated positively with IL-6 and the mRS, and CD40L levels with IL-17A and the mRS. Higher PTX3 and CD40L levels may reflect the underlying neuroinflammation.

引用

页码：40 / 44

页数：5

共 38 条

[1] Genomic regulation after CD40 stimulation in microglia: Relevance to Alzheimer's disease
Ait-Ghezala, G
Mathura, VS
Laporte, V
Quadros, A
Paris, D
Patel, N
Volmar, CH
Kolippakkam, D
Crawford, F
Mullan, M
[J]. MOLECULAR BRAIN RESEARCH, 2005, 140 (1-2): : 73 - 85
[2] ALLES VV, 1994, BLOOD, V84, P3483
[3] Platelet-derived CD40L -: The switch-hitting player of cardiovascular disease
André, P
Nannizzi-Alaimo, L
Prasad, SK
Phillips, DR
[J]. CIRCULATION, 2002, 106 (08) : 896 - 899
[4] Characterization of the promoter for the human long pentraxin PTX3 - Role of NF-kappa B in tumor necrosis factor-alpha and interleukin-1 beta regulation
Basile, A
Sica, A
dAniello, E
Breviario, F
Garrido, G
Castellano, M
Mantovani, A
Introna, M
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (13) : 8172 - 8178
[5] CD40/CD40L signaling and its implication in health and disease
Chatzigeorgiou, Antonios
Lyberi, Maria
Chatzilymperis, Gregorios
Nezos, Adrianos
Kamper, Elli
[J]. BIOFACTORS, 2009, 35 (06) : 474 - 483
[6] Complement dependent amplification of the innate response to a cognate microbial ligand by the long pentraxin PTX31
Cotena, Alessia
Maina, Virginia
Sironi, Marina
Bottazzi, Barbara
Jeannin, Pascale
Vecchi, Annunciata
Corvaia, Nathalie
Daha, Mohamed R.
Mantovani, Alberto
Garlanda, Cecilia
[J]. JOURNAL OF IMMUNOLOGY, 2007, 179 (09) : 6311 - 6317
[7] CD40-CD40L interactions induce chemokine expression by human microglia - Implications for human immunodeficiency virus encephalitis and multiple sclerosis
D'Aversa, TG
Weidenheim, KM
Berman, JW
[J]. AMERICAN JOURNAL OF PATHOLOGY, 2002, 160 (02) : 559 - 567
[8] Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma
Dalmau, Josep
Tuzun, Erdem
Wu, Hai-yan
Masjuan, Jaime
Rossi, Jeffrey E.
Voloschin, Alfredo
Baehring, Joachim M.
Shimazaki, Haruo
Koide, Rej
King, Dale
Mason, Warren
Sansing, Lauren H.
Dichter, Marc A.
Rosenfeld, Myrna R.
Lynch, David R.
[J]. ANNALS OF NEUROLOGY, 2007, 61 (01) : 25 - 36
[9] Th1 and Th17 cells Adversaries and collaborators
Damsker, Jesse M.
Hansen, Anna M.
Caspi, Rachel R.
[J]. YEAR IN IMMUNOLOGY 2, 2010, 1183 : 211 - 221
[10] Danese S, 2005, CRIT REV IMMUNOL, V25, P103

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