Correlations among the frequencies of atrial activity on the surface electrocardiogram, intracardiac atrial electrograms, and the atrial effective refractory period in patients with atrial fibrillation

Background: The frequency of surface atrial electrocardiogram (ECG) depolarization has been postulated to reflect the atrial effective refractory period (AERP). Methods: Frequency analysis of surface ECGs after QRST subtraction and of electrograms from 4 right atrium and 4 coronary sinus electrode pairs was performed in 38 patients in atrial fibrillation. The AERP was measured in the right atrium and coronary sinus 10 minutes after cardioversion. Results: The correlation between the dominant frequencies of intracardiac electrograms and atrial activity in leads I, II, and V-1 were 0.89, 0.85, and 0.88, respectively (all P < .001). The correlation between the average AERP and the frequency of atrial activity in the surface leads was 0.50, 0.45, and 0.47 (all P < .005). Conclusion: In atrial fibrillation, the frequency of atrial depolarization measured from the surface ECG is highly correlated with intracardiac atrial frequency. However, the correlation between the frequency of surface atrial activity and atrial refractoriness, although significant, is not strong. Published by Elsevier Inc.