Survival control of malignant lymphocytes by anti-apoptotic MCL-1

被引：35

作者：

Fernandez-Marrero, Y. ^{[1
]}

Spinner, S. ^{[2
]}

Kaufmann, T. ^{[1
]}

Jost, P. J. ^{[2
]}

机构：

[1] Univ Bern, Fac Med, Inst Pharmacol, Bern, Switzerland

[2] Tech Univ Munich, Klinikum Rechts Isar, Med Dept Hematol & Oncol 3, Ismaningerstr 22, D-81675 Munich, Germany

来源：

LEUKEMIA | 2016年 / 30卷 / 11期

基金：

瑞士国家科学基金会;

关键词：

T-CELL LYMPHOMA; BCL-2 FAMILY PROTEINS; NON-HODGKINS-LYMPHOMA; STRUCTURE-GUIDED DESIGN; GENOME-WIDE ANALYSIS; DOWN-REGULATION; IN-VITRO; B-CELLS; ANAPLASTIC LYMPHOMA; SIGNALING PATHWAY;

D O I：

10.1038/leu.2016.213

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Programmed apoptotic cell death is critical to maintain tissue homeostasis and cellular integrity in the lymphatic system. Accordingly, the evasion of apoptosis is a critical milestone for the transformation of lymphocytes on their way to becoming overt lymphomas. The anti-apoptotic BCL-2 family proteins are pivotal regulators of the mitochondrial apoptotic pathway and genetic aberrations in these genes are associated with lymphomagenesis and chemotherapeutic resistance. Pharmacological targeting of BCL-2 is highly effective in certain indolent B-cell lymphomas; however, recent evidence highlights a critical role for the BCL-2 family member MCL-1 in several lymphoma subtypes. MCL-1 is recurrently highly expressed in various kinds of cancer including non-Hodgkin's lymphoma of B-and T-cell origin. Moreover, both indolent and aggressive forms of lymphoma require MCL-1 for lymphomagenesis and for their continued survival. This review summarizes the role of MCL-1 in B-and T-cell lymphoma and discusses its potential as a therapeutic target.

引用

页码：2152 / 2159

页数：8

共 100 条

[51] Cytogenetic abnormalities and clinical correlations in peripheral T-cell lymphoma [J].

Nelson, Marilu ;

Horsman, Douglas E. ;

Weisenburger, Dennis D. ;

Gascoyne, Randy D. ;

Dave, Bhavana J. ;

Loberiza, Fausto R. ;

Ludkovski, Olga ;

Savage, Kerry J. ;

Armitage, James O. ;

Sanger, Warren G. .

BRITISH JOURNAL OF HAEMATOLOGY, 2008, 141 (04) :461-469

[52] An inhibitor of Bcl-2 family proteins induces regression of solid tumours [J].

Oltersdorf, T ;

Elmore, SW ;

Shoemaker, AR ;

Armstrong, RC ;

Augeri, DJ ;

Belli, BA ;

Bruncko, M ;

Deckwerth, TL ;

Dinges, J ;

Hajduk, PJ ;

Joseph, MK ;

Kitada, S ;

Korsmeyer, SJ ;

Kunzer, AR ;

Letai, A ;

Li, C ;

Mitten, MJ ;

Nettesheim, DG ;

Ng, S ;

Nimmer, PM ;

O'Connor, JM ;

Oleksijew, A ;

Petros, AM ;

Reed, JC ;

Shen, W ;

Tahir, SK ;

Thompson, CB ;

Tomaselli, KJ ;

Wang, BL ;

Wendt, MD ;

Zhang, HC ;

Fesik, SW ;

Rosenberg, SH .

NATURE, 2005, 435 (7042) :677-681

[53] Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1 [J].

Opferman, JT ;

Letai, A ;

Beard, C ;

Sorcinelli, MD ;

Ong, CC ;

Korsmeyer, SJ .

NATURE, 2003, 426 (6967) :671-676

[54] Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells [J].

Opferman, JT ;

Iwasaki, H ;

Ong, CC ;

Suh, H ;

Mizuno, S ;

Akashi, K ;

Korsmeyer, SJ .

SCIENCE, 2005, 307 (5712) :1101-1104

[55] High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells [J].

Oppermann, Sina ;

Ylanko, Jarkko ;

Shi, Yonghong ;

Hariharan, Santosh ;

Oakes, Christopher C. ;

Brauer, Patrick M. ;

Zuniga-Pflucker, Juan C. ;

Leber, Brian ;

Spaner, David E. ;

Andrews, David W. .

BLOOD, 2016, 128 (07) :934-947

[56] Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy [J].

Pattingre, S ;

Tassa, A ;

Qu, XP ;

Garuti, R ;

Liang, XH ;

Mizushima, N ;

Packer, M ;

Schneider, MD ;

Levine, B .

CELL, 2005, 122 (06) :927-939

[57] The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma [J].

Pechloff, Konstanze ;

Holch, Julian ;

Ferch, Uta ;

Schweneker, Marc ;

Brunner, Kristina ;

Kremer, Markus ;

Sparwasser, Tim ;

Quintanilla-Martinez, Leticia ;

Zimber-Strobl, Ursula ;

Streubel, Berthold ;

Gewies, Andreas ;

Peschel, Christian ;

Ruland, Juergen .

JOURNAL OF EXPERIMENTAL MEDICINE, 2010, 207 (05) :1031-1044

[58] Mcl-1 is essential for the survival of plasma cells [J].

Peperzak, Victor ;

Vikstroem, Ingela ;

Walker, Jennifer ;

Glaser, Stefan P. ;

LePage, Melanie ;

Coquery, Christine M. ;

Erickson, Loren D. ;

Fairfax, Kirsten ;

Mackay, Fabienne ;

Strasser, Andreas ;

Nutt, Stephen L. ;

Tarlinton, David M. .

NATURE IMMUNOLOGY, 2013, 14 (03) :290-297

[59] Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration [J].

Perciavalle, Rhonda M. ;

Stewart, Daniel P. ;

Koss, Brian ;

Lynch, John ;

Milasta, Sandra ;

Bathina, Madhavi ;

Temirov, Jamshid ;

Cleland, Megan M. ;

Pelletier, Stephane ;

Schuetz, John D. ;

Youle, Richard J. ;

Green, Douglas R. ;

Opferman, Joseph T. .

NATURE CELL BIOLOGY, 2012, 14 (06) :575-+

[60] Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies [J].

Peterson, Luke F. ;

Sun, Hanshi ;

Liu, Yihong ;

Potu, Harish ;

Kandarpa, Malathi ;

Ermann, Monika ;

Courtney, Stephen M. ;

Young, Matthew ;

Showalter, Hollis D. ;

Sun, Duxin ;

Jakubowiak, Andrzej ;

Malek, Sami N. ;

Talpaz, Moshe ;

Donato, Nicholas J. .

BLOOD, 2015, 125 (23) :3588-3597

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