Application of NIR Raman spectroscopy for detecting and characterizing early dental caries

被引：1

作者：

Ko, A. C. -T. ^{[1
]}

Choo-Smith, L. -P. ^{[1
,2
]}

Zhu, R. ^{[1
]}

Hewko, M. ^{[1
]}

Dong, C. ^{[2
]}

Cleghorn, B. ^{[3
]}

Sowa, M. G. ^{[1
]}

机构：

[1] Natl Res Council Canada, Inst Biodiagnost, 435 Ellice Ave, Winnipeg, MB R3B 1Y6, Canada

[2] Univ Manitoba, Fac Dent, Dept Restorat Dent, Winnipeg, MB R3E OW2, Canada

[3] Dalhousie Univ, Fac Dent, Dept Dent Clin Sci, Halifax, NS B3H 3J5, Canada

来源：

BIOMEDICAL VIBRATIONAL SPECTROSCOPY III: ADVANCES IN RESEARCH AND INDUSTRY | 2006年 / 6093卷

基金：

加拿大健康研究院;

关键词：

Raman spectroscopy; dental caries; depolarization ratio; polarization anisotropy; hydroxyapatite;

D O I：

10.1117/12.647159

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Early dental caries detection facilitates implementation of non-surgical methods for arresting caries progression and promoting tooth remineralization. We present a method based on Raman spectroscopy with near-IR laser excitation to provide biochemical contrast for detecting and characterizing incipient carious lesions found in extracted human teeth. Changes in Raman spectra are observed in PO43- vibrations arising from hydroxyapatite of mineralized tooth tissue. Examination of various intensities of the PO43- nu(2), nu(3), nu(4) vibrations showed consistent increased intensities in spectra of carious lesions compared to sound enamel. The spectral changes are attributed to demineralization-induced alterations of enamel crystallite morphology and/or orientation. This hypothesis is supported by reduced Raman polarization anisotropy derived from polarized Raman spectra of carious lesions. Polarized Raman spectral imaging of carious lesions found on whole (i.e. un-sectioned) tooth samples will also be presented.

引用

页数：10

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