Abnormal Development of Peripheral Lymphoid Organs in Mice Deficient in Lymphotoxin

被引：804

作者：

De Togni, Pietro ^{[1
]}

Goellner, Josphe ^{[2
]}

Ruddle, Nancy H. ^{[3
]}

Streeter, Philip R. ^{[2
]}

Fick, Andrea ^{[4
]}

Mariathasan, Sanjeev ^{[4
]}

Smith, Stacy C. ^{[1
]}

Carison, Rebecca ^{[4
]}

Shonnick, Laurie P. ^{[1
]}

strauss-Schoenberger, Jena ^{[2
]}

Russell, John H. ^{[5
]}

Karr, Robert ^{[2
]}

Chaplin, David D. ^{[4
]}

机构：

[1] Washington Univ, Sch Med, Dept Internal Med, St Louis, MO 63110 USA

[2] Monsanto Co, Dept Immunol, St Louis, MO 63198 USA

[3] Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06510 USA

[4] Washington Univ, Sch Med, Howard Hughes Med Inst, St Louis, MO 63110 USA

[5] Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA

来源：

JOURNAL OF IMMUNOLOGY | 2014年 / 192卷 / 05期

关键词：

TUMOR-NECROSIS-FACTOR; FACTOR-BETA LYMPHOTOXIN; FACTOR-ALPHA; INTERFERON-GAMMA; EXPRESSION; CELLS; ACTIVATION; PROLIFERATION; CYTOTOXICITY; LYMPHOCYTES;

D O I：

10.1126/science.8171322

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mice rendered deficient in lymphotoxin (LT) by gene targeting in embryonic stem cells have no morphologically detectable lymph nodes or Peyer's patches, although development of the thymus appears normal. Within the white pulp of the spleen, there is failure of normal segregation of B and T cells. Spleen and peripheral blood contain CD4(+)CD8(-) and CD4(-)CD8(+) T cells in a normal ratio, and both T cell subsets have an apparently normal lytic function. Lymphocytes positive for immunoglobulin M are present in increased numbers in both the spleen and peripheral blood. These data suggest an essential role for LT in the normal development of peripheral lymphoid organs.

引用

页码：2010 / 2014

页数：5

共 36 条

[1]

BROUDY VC, 1987, J IMMUNOL, V138, P4298

[2] LYMPHOTOXIN-BETA, A NOVEL MEMBER OF THE TNF FAMILY THAT FORMS A HETEROMERIC COMPLEX WITH LYMPHOTOXIN ON THE CELL-SURFACE [J].

BROWNING, JL ;

NGAMEK, A ;

LAWTON, P ;

DEMARINIS, J ;

TIZARD, R ;

CHOW, EPC ;

HESSION, C ;

OBRINEGRECO, B ;

FOLEY, SF ;

WARE, CF .

CELL, 1993, 72 (06) :847-856

[3] CACHECTIN TUMOR NECROSIS FACTOR-ALPHA FORMATION IN HUMAN DECIDUA - POTENTIAL ROLE OF CYTOKINES IN INFECTION-INDUCED PRETERM LABOR [J].

CASEY, ML ;

COX, SM ;

BEUTLER, B ;

MILEWICH, L ;

MACDONALD, PC .

JOURNAL OF CLINICAL INVESTIGATION, 1989, 83 (02) :430-436

[4] MOLECULAR MAP OF THE MURINE S-REGION [J].

CHAPLIN, DD ;

WOODS, DE ;

WHITEHEAD, AS ;

GOLDBERGER, G ;

COLTEN, HR ;

SEIDMAN, JG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (22) :6947-6951

[5]

CONTA BS, 1985, J IMMUNOL, V134, P2185

[6] A Lymphotoxin-β-Specific Receptor [J].

Crowe, Paul D. ;

VanArsdale, Todd L. ;

Walter, Barbara N. ;

Ware, Carl F. ;

Hession, Catherine ;

Ehrenfels, Barbara ;

Browning, Jeffrey L. ;

Din, Wenie S. ;

Goodwin, Raymond G. ;

Smith, Craig A. .

JOURNAL OF IMMUNOLOGY, 2014, 192 (05) :2015-2018

[7] TUMOR-NECROSIS-FACTOR-ALPHA IS INVOLVED IN MOUSE GROWTH AND LYMPHOID-TISSUE DEVELOPMENT [J].

DEKOSSODO, S ;

GRAU, GE ;

DANEVA, T ;

POINTAIRE, P ;

FOSSATI, L ;

ODY, C ;

ZAPF, J ;

PIGUET, PF ;

GAILLARD, RC ;

VASSALLI, P .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (05) :1259-1264

[8]

EARDLEY DD, 1980, J IMMUNOL, V124, P1199

[9] CONSTITUTIVE SYNTHESIS OF TUMOR-NECROSIS-FACTOR IN THE THYMUS [J].

GIROIR, BP ;

BROWN, T ;

BEUTLER, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (11) :4864-4868

[10] LYMPHOCYTE CYTOTOXICITY IN VITRO - ACTIVATION AND RELEASE OF A CYTOTOXIC FACTOR [J].

GRANGER, GA ;

WILLIAMS, TW .

NATURE, 1968, 218 (5148) :1253-&

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