Apathy Is Associated With Increased Amyloid Burden in Mild Cognitive Impairment

被引：55
作者：
Marshall, Gad A. [1 ,2 ]
Donovan, Nancy J.
Lorius, Natacha [1 ,2 ,3 ]
Gidicsin, Christopher M.
Maye, Jacqueline
Pepin, Lesley C.
Becker, J. Alex
Amariglio, Rebecca E. [1 ,2 ,3 ]
Rentz, Dorene M. [1 ,2 ,3 ]
Sperling, Reisa A. [1 ,2 ]
Johnson, Keith A. [1 ,2 ,4 ]
机构：
[1] Harvard Univ, Sch Med, Ctr Alzheimer Res & Treatment, Brigham & Womens Hosp, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Neurol, Brigham & Womens Hosp, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Dept Psychiat, Brigham & Womens Hosp, Boston, MA 02115 USA
[4] Harvard Univ, Sch Med, Dept Radiol, Massachusetts Gen Hosp, Boston, MA 02115 USA
来源：
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | 2013年 / 25卷 / 04期
关键词：
ALZHEIMERS-DISEASE; NEUROPSYCHIATRIC INVENTORY; INSTRUMENTAL ACTIVITIES; EXECUTIVE FUNCTION; DEPOSITION; DEMENTIA; PSYCHOPATHOLOGY; DEPRESSION;
D O I：
10.1176/appi.neuropsych.12060156
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Apathy is the most common neuropsychiatric symptom in mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia. The authors sought to determine whether apathy is associated with cortical amyloid burden, as measured by Pittsburgh Compound B (PiB) positron emission tomography (PET), and regional hypometabolism, measured by 18F-fluorodeoxyglocuse (FDG) PET in MCI. The authors found a significant association between increased apathy (lower Apathy Evaluation Scale score) and greater cortical PiB retention independent of age, but no significant association between apathy and regional FDG metabolism. These results suggest that increased apathy is associated with greater amyloid burden but not regional hypometabolism in MCI.
引用
收藏
页码：302 / 307
页数：6
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