Strategic white matter hyperintensity locations for cognitive impairment: A multicenter lesion-symptom mapping study in 3525 memory clinic patients

被引：29

作者：

Coenen, Mirthe ^{[1
]}

Kuijf, Hugo J. ^{[2
]}

Wajer, Irene M. C. Huenges ^{[1
,3
]}

Duering, Marco ^{[4
,5
,28
]}

Wolters, Frank J. ^{[6
,7
,8
]}

Fletcher, Evan F. ^{[9
]}

Maillard, Pauline M. ^{[9
]}

Barkhof, Frederik ^{[10
,11
]}

Barnes, Josephine ^{[12
]}

Benke, Thomas ^{[13
]}

Boomsma, Jooske M. F. ^{[14
]}

Chen, Christopher P. L. H. ^{[15
,16
]}

Dal-Bianco, Peter ^{[17
]}

Dewenter, Anna ^{[4
]}

Enzinger, Christian ^{[18
,19
]}

Ewers, Michael G. ^{[4
]}

Exalto, Lieza ^{[1
,2
]}

Franzmeier, Nicolai ^{[4
]}

Groeneveld, Onno ^{[1
,20
]}

Hilal, Saima ^{[15
,16
,21
]}

Hofer, Edith L. ^{[22
,23
]}

Koek, Dineke B. ^{[24
]}

Maier, Andrea R. ^{[16
,25
]}

McCreary, Cheryl S. ^{[26
]}

Padilla, Catarina M.

Papma, Janne W.

Paterson, Ross

Pijnenburg, Yolande A. L.

Rubinski, Anna ^{[4
]}

Schmidt, Reinhold M.

Schott, Jonathan F.

Slattery, Catherine E.

Smith, Eric

Steketee, Rebecca M. E. H. ^{[6
,8
]}

Sudre, Carole ^{[28
]}

van den Berg, Esther M. ^{[8
,27
]}

van der Flier, Wiesje ^{[14
]}

Venketasubramanian, Narayanaswamy W. ^{[16
,29
]}

Vernooij, Meike ^{[6
,7
,8
]}

Xin, Xu ^{[15
,16
]}

DeCarli, Charles

Biessels, Geert Jan ^{[1
]}

Biesbroek, J. Matthijs ^{[1
,30
]}

机构：

[1] UMC Utrecht, Brain Ctr, Dept Neurol & Neurosurg, Utrecht, Netherlands

[2] Univ Med Ctr Utrecht, Image Sci Inst, Utrecht, Netherlands

[3] Univ Utrecht, Helmholtz Inst, Expt Psychol, Utrecht, Netherlands

[4] Ludwig Maximilians Univ Munchen, Univ Hosp, Inst Stroke & Dementia Res ISD, Munich, Germany

[5] Univ Basel, Med Image Anal Ctr MIAC, Dept Biomed Engn, Basel, Switzerland

[6] Erasmus MC, Dept Radiol & Nucl Med, Univ Med Ctr, Rotterdam, Netherlands

[7] Erasmus MC, Dept Epidemiol, Univ Med Ctr, Rotterdam, Netherlands

[8] Erasmus MC, Alzheimer Ctr Erasmus MC, Univ Med Ctr, Rotterdam, Netherlands

[9] Univ Calif Davis, Dept Neurol, Davis, CA USA

[10] Locat Vrije Univ, Radiol & Nucl Med, Amsterdam UMC, Amsterdam, Netherlands

[11] UCL Inst Neurol, London, England

[12] UCL, UCL Queen Sq Inst Neurol, Dementia Res Ctr, London, England

[13] Med Univ Innsbruck, Clin Neurol, Innsbruck, Austria

[14] Vrije Univ Amsterdam, Amsterdam, Netherlands

[15] Natl Univ Singapore, Dept Pharmacol, Singapore, Singapore

[16] Natl Univ Hlth Syst, Memory Aging & Cognit Ctr, Singapore, Singapore

[17] Med Univ Vienna, Dept Neurol, Vienna, Austria

[18] Med Univ Graz, Dept Neurol, Div Gen Neurol, Graz, Austria

[19] Med Univ Graz, Dept Radiol, Div Neuroradiol Intervent & Vasc Radiol, Graz, Austria

[20] Isala Hosp, Isala MS Ctr, Dept Neurol, Meppel, Netherlands

[21] Natl Univ Singapore, Natl Univ Hlth Syst, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore

[22] Med Univ Graz, Dept Neurol, Div Neurogeriatr, Graz, Austria

[23] Med Univ Graz, Inst Med Informat, Stat & Documentat, Graz, Austria

[24] Univ Med Ctr Utrecht, Dept Geriatr Med, Utrecht, Netherlands

[25] Natl Univ Singapore, Dept Med, Singapore, Singapore

[26] Univ Calgary, Hotchkiss Brain Inst, Dept Clin Neurosci & Radiol, Calgary, AB, Canada

[27] Erasmus MC, Dept Neurol, Univ Med Ctr, Rotterdam, Netherlands

[28] UCL, Ctr Med Image Comp, MRC Unit Lifelong Hlth & Ageing, London, England

[29] Raffles Hosp, Raffles Neurosci Ctr, Singapore, Singapore

[30] Diakonessenhuis Hosp, Dept Neurol, Utrecht, Netherlands

来源：

ALZHEIMERS & DEMENTIA | 2022年

基金：

奥地利科学基金会; 美国国家卫生研究院;

关键词：

cognitive impairment; lesion symptom mapping; location; memory clinic patients; white matter hyperintensities; PROCESSING SPEED DEFICITS; SMALL VESSEL DISEASE; TRACTS; DEMENTIA;

D O I：

10.1002/alz.12827

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

IntroductionImpact of white matter hyperintensities (WMH) on cognition likely depends on lesion location, but a comprehensive map of strategic locations is lacking. We aimed to identify these locations in a large multicenter study. MethodsIndividual patient data (n = 3525) from 11 memory clinic cohorts were harmonized. We determined the association of WMH location with attention and executive functioning, information processing speed, language, and verbal memory performance using voxel-based and region of interest tract-based analyses. ResultsWMH in the left and right anterior thalamic radiation, forceps major, and left inferior fronto-occipital fasciculus were significantly related to domain-specific impairment, independent of total WMH volume and atrophy. A strategic WMH score based on these tracts inversely correlated with performance in all domains. DiscussionThe data show that the impact of WMH on cognition is location-dependent, primarily involving four strategic white matter tracts. Evaluation of WMH location may support diagnosing vascular cognitive impairment. HighlightsWe analyzed white matter hyperintensities (WMH) in 3525 memory clinic patients from 11 cohortsThe impact of WMH on cognition depends on locationWe identified four strategic white matter tractsA single strategic WMH score was derived from these four strategic tractsThe strategic WMH score was an independent determinant of four cognitive domains

引用

页码：2420 / 2432

页数：13

共 42 条

[1] Clinical associations of T2-weighted lesion load and lesion location in small vessel disease: Insights from a large prospective cohort study
Altermatt, Anna
Gaetano, Laura
Magon, Stefano
Bauer, Lorena
Feurer, Regina
Gnahn, Hans
Hartmann, Julia
Seifert, Christian L.
Poppert, Holger
Wuerfel, Jens
Radue, Ernst-Wilhelm
Kappos, Ludwig
Sprenger, Till
[J]. NEUROIMAGE, 2019, 189 : 727 - 733
[2] A Novel Imaging Marker for Small Vessel Disease Based on Skeletonization of White Matter Tracts and Diffusion Histograms
Baykara, Ebru
Gesierich, Benno
Adam, Ruth
Tuladhar, Anil Man
Biesbroek, J. Matthijs
Koek, Huiberdina L.
Ropele, Stefan
Jouvent, Eric
Chabriat, Hugues
Ertl-Wagner, Birgit
Ewers, Michael
Schmidt, Reinhold
de Leeuw, Frank-Erik
Biessels, Geert Jan
Dichgans, Martin
Duering, Marco
[J]. ANNALS OF NEUROLOGY, 2016, 80 (04) : 581 - 592
[3] Pulvinar Associative role in cortical function and clinical correlations
Benarroch, Eduardo E.
[J]. NEUROLOGY, 2015, 84 (07) : 738 - 747
[4] Diagnosing vascular cognitive impairment: Current challenges and future perspectives
Biesbroek, J. Matthijs
Biessels, Geert Jan
[J]. INTERNATIONAL JOURNAL OF STROKE, 2023, 18 (01) : 36 - 43
[5] High white matter hyperintensity burden in strategic white matter tracts relates to worse global cognitive performance in community-dwelling individuals
Biesbroek, J. Matthijs
Lam, Bonnie Y. K.
Zhao, Lei
Tang, Yumi
Wang, Zhaolu
Abrigo, Jill
Chu, Winnie W. C.
Wong, Adrian
Shi, Lin
Kuijf, Hugo J.
Biessels, Geert Jan
Mok, Vincent C. T.
[J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 2020, 414
[6] Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
Biesbroek, J. Matthijs
Kuijf, Hugo J.
Weaver, Nick A.
Zhao, Lei
Duering, Marco
Biessels, Geert Jan
[J]. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2019, (151):
[7] Lesion location and cognitive impact of cerebral small vessel disease
Biesbroek, J. Matthijs
Weaver, Nick A.
Biessels, Geert Jan
[J]. CLINICAL SCIENCE, 2017, 131 (08) : 715 - 728
[8] Impact of Strategically Located White Matter Hyperintensities on Cognition in Memory Clinic Patients with Small Vessel Disease
Biesbroek, J. Matthijs
Weaver, Nick A.
Hilal, Saima
Kuijf, Hugo J.
Ikram, Mohammad Kamran
Xu, Xin
Tan, Boon Yeow
Venketasubramanian, Narayanaswamy
Postman, Albert
Biessels, Geert Jan
Chen, Christopher P. L. H.
[J]. PLOS ONE, 2016, 11 (11):
[9] Association between Subcortical Vascular Lesion Location and Cognition: A Voxel-Based and Tract-Based Lesion-Symptom Mapping Study. The SMART-MR Study
Biesbroek, J. Matthijs
Kuijf, Hugo J.
van der Graaf, Yolanda
Vincken, Koen L.
Postma, Albert
Mali, Willem P. T. M.
Biessels, Geert J.
Geerlings, Mirjam I.
[J]. PLOS ONE, 2013, 8 (04):
[10] Boomsma Jooske Marije Funke, 2017, JMIR Res Protoc, V6, pe60, DOI 10.2196/resprot.6864

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