Synthesis, characterization, swelling and drug release behavior of semi-interpenetrating network hydrogels of sodium alginate and polyacrylamide

被引：225
|
作者：
Samanta, Himadri Sekhar [1 ]
Ray, Samit Kumar [1 ]
机构：
[1] Univ Calcutta 92, Dept Polymer Sci & Technol, Kolkata 700009, India
来源：
CARBOHYDRATE POLYMERS | 2014年 / 99卷
关键词：
Sodium alginate; Acrylamide; Semi-IPN hydrgels; Characterization; Drug release; SUPERABSORBENT HYDROGELS; SUPERPOROUS HYDROGELS; POLYMER NETWORKS; REMOVAL; DYES; PARAMETERS; DELIVERY; METHACRYLATE); ACRYLATE); COPOLYMER;
D O I：
10.1016/j.carbpol.2013.09.004
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Several semi interpenetrating network (SIPN) type hydrogels were synthesized by in-situ free radical crosslink copolymerization of acrylamide and crosslinker N,N'-methylene bisacrylamide (MBA) in aqueous solution of sodium alginate (SA). These SIPN hydrogels were characterized by FTIR, NMR SEM, DTA-TGA, XRD, PZC and also by swelling characteristics and network parameters. Adsorption (loading) and release of acetaminophen drug were studied with these hydrogels. Solution pH, crosslinker concentration and monomer to SA weight ratio of the hydrogels were found to have a strong effect on adsorption and in vitro release profile of the drug from the gel matrix. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：666 / 678
页数：13
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