Synthesis, characterization, swelling and drug release behavior of semi-interpenetrating network hydrogels of sodium alginate and polyacrylamide

被引：242

作者：

Samanta, Himadri Sekhar ^{[1
]}

Ray, Samit Kumar ^{[1
]}

机构：

[1] Univ Calcutta 92, Dept Polymer Sci & Technol, Kolkata 700009, India

来源：

CARBOHYDRATE POLYMERS | 2014年 / 99卷

关键词：

Sodium alginate; Acrylamide; Semi-IPN hydrgels; Characterization; Drug release; SUPERABSORBENT HYDROGELS; SUPERPOROUS HYDROGELS; POLYMER NETWORKS; REMOVAL; DYES; PARAMETERS; DELIVERY; METHACRYLATE); ACRYLATE); COPOLYMER;

D O I：

10.1016/j.carbpol.2013.09.004

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Several semi interpenetrating network (SIPN) type hydrogels were synthesized by in-situ free radical crosslink copolymerization of acrylamide and crosslinker N,N'-methylene bisacrylamide (MBA) in aqueous solution of sodium alginate (SA). These SIPN hydrogels were characterized by FTIR, NMR SEM, DTA-TGA, XRD, PZC and also by swelling characteristics and network parameters. Adsorption (loading) and release of acetaminophen drug were studied with these hydrogels. Solution pH, crosslinker concentration and monomer to SA weight ratio of the hydrogels were found to have a strong effect on adsorption and in vitro release profile of the drug from the gel matrix. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：666 / 678

页数：13

共 56 条

[1] Crosslinked ionic polysaccharides for stimuli-sensitive drug delivery [J].

Alvarez-Lorenzo, Carmen ;

Blanco-Fernandez, Barbara ;

Puga, Ana M. ;

Concheiro, Angel .

ADVANCED DRUG DELIVERY REVIEWS, 2013, 65 (09) :1148-1171

[2] A systematic method of synthesizing composite superabsorbent hydrogels from crosslink copolymer for removal of textile dyes from water [J].

Bhattacharyya, Ruma ;

Ray, Samit Kumar ;

Mandal, Bidyadhar .

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 2013, 19 (04) :1191-1203

[3] CORRELATION BETWEEN MESH SIZE AND EQUILIBRIUM DEGREE OF SWELLING OF POLYMERIC NETWORKS [J].

CANAL, T ;

PEPPAS, NA .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1989, 23 (10) :1183-1193

[4] Semisynthesis of a Controlled Stimuli-Responsive Alginate Hydrogel [J].

Chan, Ariel W. ;

Whitney, Ralph A. ;

Neufeld, Ronald J. .

BIOMACROMOLECULES, 2009, 10 (03) :609-616

[5]

Chen J, 1999, J BIOMED MATER RES, V44, P53, DOI 10.1002/(SICI)1097-4636(199901)44:1<53::AID-JBM6>3.3.CO

[6]

2-N

[7] Synthesis and properties of thermo- and pH-sensitive poly(diallyldimethylammonium chloride)/poly(N,N-diethylacrylamide) semi-IPN hydrogel [J].

Chen, Jun ;

Liu, Mingzhu ;

Liu, Hongliang ;

Ma, Liwei ;

Gao, Chunmei ;

Zhu, Siying ;

Zhang, Shaopeng .

CHEMICAL ENGINEERING JOURNAL, 2010, 159 (1-3) :247-256

[8] Microwave assisted rapid method for hydrolysis of sodium alginate for M/G ratio determination [J].

Chhatbar, Mahesh ;

Meena, Ramavatar ;

Prasad, Kamalesh ;

Siddhanta, A. K. .

CARBOHYDRATE POLYMERS, 2009, 76 (04) :650-656

[9] Simple guidelines for a self-built laboratory-scale supercritical anti-solvent system [J].

Chong, G. H. ;

Yunus, R. ;

Choong, T. S. Y. ;

Abdullah, N. ;

Spotar, S. Y. .

JOURNAL OF SUPERCRITICAL FLUIDS, 2011, 60 :69-74

[10] Synthesis and characterization of a novel polymeric hydrogel based on hydroxypropyl methyl cellulose grafted with polyacrylamide [J].

Das, R. ;

Panda, A. B. ;

Pal, Sagar .

CELLULOSE, 2012, 19 (03) :933-945

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