Repurposing sodium diclofenac as a radiation countermeasure agent: A cytogenetic study in human peripheral blood lymphocytes

被引：5
|
作者：
Alok, Amit [1 ]
Agrawala, Paban K. [2 ]
机构：
[1] Inst Nucl Med & Allied Sci, Div Radiat Biodosimetry, Delhi 110054, India
[2] Inst Nucl Med & Allied Sci, Radiat Genet & Epigenet, Brig S K Mazumdar Marg, Delhi 110054, India
来源：
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 2020年 / 856卷
关键词：
Radioprotector; Radiomitigator; Dicentric chromosome; Micronuclei; gamma-H2AX; TOXICITY; MICE; THERAPY; INJURY;
D O I：
10.1016/j.mrgentox.2020.503220
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
We assessed the radioprotective and mitigative actions of sodium diclofenac, a non-steroidal anti-inflammatory drug using cultured human peripheral blood as a model. Both pre- and post-irradiation treatments with the drug reduced gamma radiation-induced formation of dicentric chromosome, cytochalasin-blocked micronuclei and gamma-H2AX foci in human peripheral blood lymphocytes. This work supports the concept that sodium diclofenac may be a useful radiation countermeasure agent.
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页数：6
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