Genome-scale analyses of health-promoting bacteria: probiogenomics

被引:365
作者
Ventura, Marco [3 ]
O'Flaherty, Sarah [4 ]
Claesson, Marcus J. [1 ,2 ]
Turroni, Francesca [3 ]
Klaenhammer, Todd R. [4 ]
van Sinderen, Douwe [1 ,2 ]
O'Toole, Paul W. [1 ,2 ]
机构
[1] Univ Coll Cork, Alimentary Pharmabiot Ctr, Cork, Ireland
[2] Univ Coll Cork, Dept Microbiol, Cork, Ireland
[3] Univ Parma, Dept Genet, I-43100 Parma, Italy
[4] N Carolina State Univ, Dept Bioproc & Nutr Sci, Raleigh, NC 27695 USA
基金
爱尔兰科学基金会;
关键词
JOHNSONII STRAIN NCC533; LACTIC-ACID BACTERIA; LACTOBACILLUS-PLANTARUM; BIFIDOBACTERIUM-LONGUM; BETA-FRUCTOFURANOSIDASE; GASTROINTESTINAL-TRACT; MUCIN DEGRADATION; FECAL MICROBIOTA; CROHNS-DISEASE; GUT MICROBIOTA;
D O I
10.1038/nrmicro2047
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The human body is colonized by an enormous population of bacteria (microbiota) that provides the host with coding capacity and metabolic activities. Among the human gut microbiota are health-promoting indigenous species (probiotic bacteria) that are commonly consumed as live dietary supplements. Recent genomics-based studies (probiogenomics) are starting to provide insights into how probiotic bacteria sense and adapt to the gastrointestinal tract environment. In this Review, we discuss the application of probiogenomics in the elucidation of the molecular basis of probiosis using the well-recognized model probiotic bacteria genera Bifidobacterium and Lactobacillus as examples.
引用
收藏
页码:61 / U77
页数:13
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