Fibroblasts in cancer

被引：3627
作者：
Kalluri, R [1 ]
Zeisberg, M
机构：
[1] Beth Israel Deaconess Med Ctr, Ctr Matrix Biol, Boston, MA 02215 USA
[2] Harvard Mit Div Hlth Sci & Technol, Boston, MA 02215 USA
[3] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02215 USA
来源：
NATURE REVIEWS CANCER | 2006年 / 6卷 / 05期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrc1877
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tumours are known as wounds that do not heal - this implies that cells that are involved in angiogenesis and the response to injury, such as endothelial cells and fibroblasts, have a prominent role in the progression, growth and spread of cancers. Fibroblasts are associated with cancer cells at all stages of cancer progression, and their structural and functional contributions to this process are beginning to emerge. Their production of growth factors, chemokines and extracellular matrix facilitates the angiogenic recruitment of endothelial cells and pericytes. Fibroblasts are therefore a key determinant in the malignant progression of cancer and represent an important target for cancer therapies.
引用
收藏
页码：392 / 401
页数：10
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