Near Full-Length Genomic Sequences of Two Novel HIV-1 Recombinant Forms Identified in Shenzhen, China

被引：1

作者：

Jia, Dijing ^{[1
]}

Zhao, Jin ^{[2
]}

Li, Tianyi ^{[3
]}

Sun, Changrong ^{[3
]}

Li, Hanping ^{[3
]}

Zheng, Chenli ^{[2
]}

Chen, Lin ^{[2
]}

Liu, Yongjian ^{[3
]}

Liu, Siyang ^{[3
]}

Zhuang, Daomin ^{[3
]}

Wang, Xiaolin ^{[3
]}

Bao, Zuoyi ^{[3
]}

Li, Jingyun ^{[3
]}

Li, Lin ^{[1
,3
]}

机构：

[1] Anhui Med Univ, Grad Sch, Hefei, Anhui, Peoples R China

[2] Shenzhen Ctr Dis Control & Prevent, Shenzhen, Peoples R China

[3] Beijing Inst Microbiol & Epidemiol, Dept AIDS Res, State Key Lab Pathogen & Biosecur, 20 Dongda St, Beijing 100071, Peoples R China

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2017年 / 33卷 / 01期

基金：

中国国家自然科学基金;

关键词：

HIV; URF; HIV genetics; China; WESTERN YUNNAN; CRF07-BC; CRF01-AE; STRAIN;

D O I：

10.1089/aid.2016.0162

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Most HIV subtypes prevalent in China can be found in Shenzhen, including CRF07_BC, CRF01_AE, CRF08_BC, CRF55_01B, and subtype B. Multiple subtypes spreading in the same population always lead to the emergence of unique recombinant strains. Here, we report two unique recombinant forms (SZ44LS7251 and SZ95LS8027) of HIV-1 identified in a heterosexual population. Recombinant analyses were fulfilled based on the near full-length genomes. Both strains comprise subtypes B, C, and CRF01_AE. Phylogenetic analysis reveals that SZ44LS7251 is the second generation recombination originated from CRF55_01B andCRF07_BC, whereas SZ95LS8027 comprises CRF01_AE and CRF07_BC. The emergence of second generation recombination of HIV with complicated genomic structures supposed that high ratio of super infections or coinfections might happen in the Shenzhen area.

引用

页码：82 / 86

页数：5

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