Cytokines in heart failure: Pathogenetic mechanisms and potential treatment

被引：51
作者：
Dibbs, Z
Kurrelmeyer, K
Kalra, D
Seta, Y
Wang, F
Bozkurt, B
Baumgarten, G
Sivasubramanian, N
Mann, DL
机构：
[1] Vet Adm Med Ctr, Dept Med, Cardiol Sect, Houston, TX 77030 USA
[2] Baylor Coll Med, Houston, TX 77030 USA
来源：
PROCEEDINGS OF THE ASSOCIATION OF AMERICAN PHYSICIANS | 1999年 / 111卷 / 05期
关键词：
cardiomyopathy; interleukin-1; interleukin-6; left ventricular remodeling; tumor necrosis factor-alpha;
D O I：
10.1111/paa.1999.111.5.423
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Recent studies have shown that patients with heart failure overexpress a class of biologically active molecules, generically referred to as pro-inflammatory cytokines. This article will review recent clinical and experimental material that suggests that pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1), and interleukin-6 (IL-6) may play a role in the pathogenesis of congestive heart failure. In addition, we will review recent studies that suggest that antagonizing cytokines may represent a novel target for heart failure therapy.
引用
收藏
页码：423 / 428
页数：6
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