Metabolite changes with age measured by proton magnetic resonance spectroscopy in normal subjects

被引：37

作者：

Fukuzako, H

Hashiguchi, T

Sakamoto, Y

Okamura, H

Doi, W

Takenouchi, K

Takigawa, M

机构：

[1] Department of Neuropsychiatry, Faculty of Medicine, Kagoshima University, Kagoshima

[2] Department of Neuropsychiatry, Faculty of Medicine, Kagoshima University, Kogoshima 890

来源：

PSYCHIATRY AND CLINICAL NEUROSCIENCES | 1997年 / 51卷 / 04期

关键词：

aging; creatine; medial temporal lobe; N-acetylaspartate; proton magnetic resonance spectroscopy;

D O I：

10.1111/j.1440-1819.1997.tb02595.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To determine whether there are metabolite changes ill the left medial temporal and frontal lobes with aging, we performed proton magnetic resonance spectroscopy in 36 normal subjects. The N-acetylaspartate/creatine-phosphocreatine ratio in the medial temporal lobe tended to be decreased in subjects over 60 years of age. The ratio decrease ill the frontal lobe related to aging was lower than that in the medial temporal lobe. There were no significant differences in the metabolite ratios between males and females. These findings suggest that structures in the medial temporal lobe may be more susceptible to neuronal dysfunction associated with aging than those in the frontal lobe.

引用

页码：261 / 263

页数：3

共 16 条

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