Aflatoxin Biosynthesis: Current Frontiers

被引:146
作者
Roze, Ludmila V. [1 ]
Hong, Sung-Yong [1 ]
Linz, John E. [1 ,2 ,3 ,4 ]
机构
[1] Michigan State Univ, Dept Food Sci & Human Nutr, E Lansing, MI 48824 USA
[2] Michigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA
[3] Michigan State Univ, Natl Food Safety & Toxicol Ctr, E Lansing, MI 48824 USA
[4] Michigan State Univ, Ctr Integrat Toxicol, E Lansing, MI 48824 USA
来源
ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 4 | 2013年 / 4卷
关键词
mycotoxin; Aspergillus; endosomes; oxidative stress; reactive oxygen species; vesicles; OXIDATIVE STRESS-RESPONSE; ASPERGILLUS-PARASITICUS GROWTH; GLUTATHIONE-S-TRANSFERASE; TRANSCRIPTION FACTOR; SECONDARY METABOLISM; SUBCELLULAR-LOCALIZATION; SACCHAROMYCES-CEREVISIAE; BACILLUS-THURINGIENSIS; FUNCTIONAL EXPRESSION; YOUNG-CHILDREN;
D O I
10.1146/annurev-food-083012-123702
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Aflatoxins are among the principal mycotoxins that contaminate economically important food and feed crops. Aflatoxin B-1 is the most potent naturally occurring carcinogen known and is also an immunosuppressant. Occurrence of aflatoxins in crops has vast economic and human health impacts worldwide. Thus, the study of aflatoxin biosynthesis has become a focal point in attempts to reduce human exposure to aflatoxins. This review highlights recent advances in the field of aflatoxin biosynthesis and explores the functional connection between aflatoxin biosynthesis, endomembrane trafficking, and response to oxidative stress. Dissection of the regulatory mechanisms involves a complete comprehension of the aflatoxin biosynthetic process and the dynamic network of transcription factors that orchestrates coordinated expression of the target genes. Despite advancements in the field, development of a safe and effective multifaceted approach to solve the aflatoxin food contamination problem is still required.
引用
收藏
页码:293 / 311
页数:19
相关论文
共 104 条