Plasma C1q/TNF-Related Protein-9 Levels Are Associated with Atherosclerosis in Patients with Type 2 Diabetes without Renal Dysfunction

被引：19

作者：

Asada, Mariko ^{[1
]}

Morioka, Tomoaki ^{[1
]}

Yamazaki, Yuko ^{[1
]}

Kakutani, Yoshinori ^{[1
]}

Kawarabayashi, Reina ^{[1
]}

Motoyama, Koka ^{[1
]}

Mori, Katsuhito ^{[1
]}

Fukumoto, Shinya ^{[2
]}

Shioi, Atsushi ^{[3
]}

Shoji, Tetsuo ^{[3
]}

Emoto, Masanori ^{[1
]}

Inaba, Andmasaaki ^{[1
]}

机构：

[1] Osaka City Univ, Grad Sch Med, Dept Metab Endocrinol & Mol Med, Abeno Ku, 1-4-3,Asahi Machi, Osaka 5458585, Japan

[2] Osaka City Univ, Grad Sch Med, Dept Premier Prevent Med, Abeno Ku, 1-4-3,Asahi Machi, Osaka 5458585, Japan

[3] Osaka City Univ, Grad Sch Med, Dept Vasc Med, Abeno Ku, 1-4-3,Asahi Machi, Osaka 5458585, Japan

来源：

JOURNAL OF DIABETES RESEARCH | 2016年 / 2016卷

基金：

日本学术振兴会;

关键词：

INTIMA-MEDIA THICKNESS; INSULIN-RESISTANCE; ADIPOSE-TISSUE; CTRP9; ADIPONECTIN; FAMILY; OBESITY; INJURY; RISK; MICE;

D O I：

10.1155/2016/8624313

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim. C1q/tumor necrosis factor-related protein-9 (CTRP9), a paralog of adiponectin, is expressed in adipose tissue. CTRP9 exerts protective effects against obesity and atherosclerosis in rodents. We investigated the association between plasma CTRP9 levels and atherosclerosis in patients with type 2 diabetes. Methods. We included 419 patients with type 2 diabetes, 161 of whom had chronic kidney disease (CKD). Fasting plasma CTRP9 and total adiponectin levels were measured with enzyme-linked immunosorbent assay. Theintima-media thickness (IMT) of the common carotid artery wasmeasuredwith ultrasonography. Results. Plasma CTRP9 levels were higher in the CKD group than in the non-CKD group. Plasma CTRP9 levels were positively correlated with carotid IMT in the non-CKD group. Multivariate analyses revealed that plasma CTRP9 levels were positively associated with carotid IMT in the non-CKD group, independent of age, sex, body mass index, adiponectin, and other cardiovascular risk factors. However, plasma CTRP9 levels were not associated with carotid IMT in the CKD group. Conclusion. Plasma CTRP9 levels are associated with atherosclerosis in diabetic patients without CKD, independently of obesity, adiponectin, and traditional cardiovascular risk factors. This study indicates a potential role of CTRP9 in atherosclerosis progression in human type 2 diabetes.

引用

页数：9

共 41 条

[1] Standards of Medical Care in Diabetes-2014 [J].