Prospects for broadly protective influenza vaccines

被引：13
作者：
Treanor, John Jay [1 ]
机构：
[1] Univ Rochester, Sch Med & Dent, Dept Med, Rochester, NY 14642 USA
来源：
VACCINE | 2015年 / 33卷
关键词：
Influenza; Vaccines; Broad protection; HEMAGGLUTININ STALK ANTIBODIES; COMPUTATIONALLY OPTIMIZED HEMAGGLUTININ; M2 EXTRACELLULAR DOMAINS; VIRUS-LIKE PARTICLES; A-VIRUS; NEURAMINIDASE ANTIBODY; PANDEMIC INFLUENZA; REACTIVE ANTIBODIES; MONOCLONAL-ANTIBODY; LETHAL INFLUENZA;
D O I：
10.1016/j.vaccine.2015.08.053
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The development of vaccines that could provide broad protection against antigenically variant influenza viruses has long been the ultimate prize in influenza research. Recent developments have pushed us closer to this goal, and such vaccines may now be within reach. This brief review outlines the current approaches to broadly protective vaccines, and the probable hurdles and roadblocks to achieving this goal. (C) 2015 by American Journal of Preventive Medicine and Elsevier Ltd. All rights reserved.
引用
收藏
页码：D39 / D45
页数：7
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