Prospects for broadly protective influenza vaccines

被引：13

作者：

Treanor, John Jay ^{[1
]}

机构：

[1] Univ Rochester, Sch Med & Dent, Dept Med, Rochester, NY 14642 USA

来源：

VACCINE | 2015年 / 33卷

关键词：

Influenza; Vaccines; Broad protection; HEMAGGLUTININ STALK ANTIBODIES; COMPUTATIONALLY OPTIMIZED HEMAGGLUTININ; M2 EXTRACELLULAR DOMAINS; VIRUS-LIKE PARTICLES; A-VIRUS; NEURAMINIDASE ANTIBODY; PANDEMIC INFLUENZA; REACTIVE ANTIBODIES; MONOCLONAL-ANTIBODY; LETHAL INFLUENZA;

D O I：

10.1016/j.vaccine.2015.08.053

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The development of vaccines that could provide broad protection against antigenically variant influenza viruses has long been the ultimate prize in influenza research. Recent developments have pushed us closer to this goal, and such vaccines may now be within reach. This brief review outlines the current approaches to broadly protective vaccines, and the probable hurdles and roadblocks to achieving this goal. (C) 2015 by American Journal of Preventive Medicine and Elsevier Ltd. All rights reserved.

引用

页码：D39 / D45

页数：7

共 85 条

[1] Identification of broad binding class I HLA supertype epitopes to provide universal coverage of influenza A virus [J].

Alexander, Jeff ;

Bilsel, Pamuk ;

del Guercio, Marie-France ;

Marinkovic-Petrovic, Aleksandra ;

Southwood, Scott ;

Stewart, Stephani ;

Ishioka, Glenn ;

Kotturi, Maya F. ;

Botten, Jason ;

Sidney, John ;

Newman, Mark ;

Sette, Alessandro .

HUMAN IMMUNOLOGY, 2010, 71 (05) :468-474

[2] Universal influenza DNA vaccine encoding conserved CD4+ T cell epitopes protects against lethal viral challenge in HLA-DR transgenic mice [J].

Alexander, Jeff ;

Bilsel, Pamuk ;

del Guercio, Marie-France ;

Stewart, Stephani ;

Marinkovic-Petrovic, Aleksandra ;

Southwood, Scott ;

Crimi, Claire ;

Vang, Lo ;

Walker, Les ;

Ishioka, Glenn ;

Chitnis, Vivek ;

Sette, Alessandro ;

Assarsson, Erika ;

Hannaman, Drew ;

Botten, Jason ;

Newman, Mark J. .

VACCINE, 2010, 28 (03) :664-672

[3] Tandem repeats of the extracellular domain of Matrix 2 influenza protein exposed in Brucella lumazine synthase decameric carrier molecule induce protection in mice [J].

Alvarez, Paula ;

Zylberman, Vanesa ;

Ghersi, Giselle ;

Boado, Lorena ;

Palacios, Carlos ;

Goldbaum, Fernando ;

Mattion, Nora .

VACCINE, 2013, 31 (05) :806-812

[4]

Andrewes CH, 1937, BRIT J EXP PATHOL, V18, P43

[5] Safety and immunogenicity of nonadjuvanted and MF59-adjuvanted influenza A/H9N2 vaccine preparations [J].

Atmar, Robert L. ;

Keitel, Wendy A. ;

Patel, Shital M. ;

Katz, Jacqueline M. ;

She, Dewei ;

El Sahly, Hana ;

Pompey, Justine ;

Cate, Thomas R. ;

Couch, Robert B. .

CLINICAL INFECTIOUS DISEASES, 2006, 43 (09) :1135-1142

[6] Priming by a novel universal influenza vaccine (Multimeric-001)-A gateway for improving immune response in the elderly population [J].

Atsmon, Jacob ;

Caraco, Yoseph ;

Ziv-Sefer, Sagit ;

Shaikevich, Dimitry ;

Abramov, Ester ;

Volokhov, Inna ;

Bruzil, Svetlana ;

Haima, Kirsten Y. ;

Gottlieb, Tanya ;

Ben-Yedidia, Tamar .

VACCINE, 2014, 32 (44) :5816-5823

[7] Efficacy of vaccination with live attenuated, cold-adapted, trivalent, intranasal influenza virus vaccine against a variant (A/Sydney) not contained in the vaccine [J].

Belshe, RB ;

Gruber, WC ;

Mendelman, PM ;

Cho, I ;

Reisinger, K ;

Block, SL ;

Wittes, J ;

Iacuzio, D ;

Piedra, P ;

Treanor, J ;

King, J ;

Kotloff, K ;

Bernstein, DI ;

Hayden, FG ;

Zangwill, K ;

Yan, LH ;

Wolff, M .

JOURNAL OF PEDIATRICS, 2000, 136 (02) :168-175

[8] ANTIBODY-RESPONSE TO THE M2-PROTEIN OF INFLUENZA A-VIRUS EXPRESSED IN INSECT CELLS [J].

BLACK, RA ;

ROTA, PA ;

GORODKOVA, N ;

KLENK, HD ;

KENDAL, AP .

JOURNAL OF GENERAL VIROLOGY, 1993, 74 :143-146

[9] Hemagglutination Inhibition Antibody Titers as a Correlate of Protection for Inactivated Influenza Vaccines in Children [J].

Black, Steven ;

Nicolay, Uwe ;

Vesikari, Timo ;

Knuf, Markus ;

Del Giudice, Giuseppe ;

Della Cioppa, Giovanni ;

Tsai, Theodore ;

Clemens, Ralf ;

Rappuoli, Rino .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2011, 30 (12) :1081-1085

[10] A high dosage influenza vaccine induced significantly more neuraminidase antibody than standard vaccine among elderly subjects [J].

Cate, Thomas R. ;

Rayford, Yolanda ;

Nino, Diane ;

Winokur, Patricia ;

Brady, Rebecca ;

Belshe, Robert ;

Chen, Wilbur ;

Atmar, Robert L. ;

Couch, Robert B. .

VACCINE, 2010, 28 (09) :2076-2079

← 1 2 3 4 5 6 7 8 9 →