Osimertinib and Cabozantinib Combinatorial Therapy in an EGFR-Mutant Lung Adenocarcinoma Patient with Multiple MET Secondary-Site Mutations after Resistance to Crizotinib

被引：51

作者：

Kang, Jin ^{[1
,2
,3
]}

Chen, Hua-Jun ^{[2
,3
]}

Wang, Zheng ^{[4
]}

Liu, Jing ^{[5
]}

Li, Bing ^{[5
]}

Zhang, Tengfei ^{[5
]}

Yang, Zhenfan ^{[4
]}

Wu, Yi-Long ^{[2
,3
,6
]}

Yang, Jin-Ji ^{[1
,2
,3
]}

机构：

[1] Guangdong Gen Hosp, Guangdong Cardiovasc Inst, Guangzhou, Guangdong, Peoples R China

[2] Guangdong Acad Med Sci, 106 Zhongshan 2nd Rd, Guangzhou 510080, Guangdong, Peoples R China

[3] Guangdong Gen Hosp, Guangdong Lung Canc Inst, 106 Zhongshan 2nd Rd, Guangzhou 510080, Guangdong, Peoples R China

[4] AstraZeneca, Asia Innovat Med, Shanghai, Peoples R China

[5] Burning Rock Biotech, Guangzhou, Guangdong, Peoples R China

[6] Guangdong Gen Hosp, Med Res Ctr, Guangzhou, Guangdong, Peoples R China

来源：

JOURNAL OF THORACIC ONCOLOGY | 2018年 / 13卷 / 04期

关键词：

ACQUIRED-RESISTANCE; CANCER;

D O I：

10.1016/j.jtho.2017.10.028

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

[No abstract available]

引用

页码：E49 / E53

页数：5

共 7 条

[1]

[Anonymous], CLIN CANC RES

[2] Acquired METD1228V Mutation and Resistance to MET Inhibition in Lung Cancer [J].

Bahcall, Magda ;

Sim, Taebo ;

Paweletz, Cloud P. ;

Patel, Jyoti D. ;

Alden, Ryan S. ;

Kuang, Yanan ;

Sacher, Adrian G. ;

Kim, Nam Doo ;

Lydon, Christine A. ;

Awad, Mark M. ;

Jaklitsch, Michael T. ;

Sholl, Lynette M. ;

Jaenne, Pasi A. ;

Oxnard, Geoffrey R. .

CANCER DISCOVERY, 2016, 6 (12) :1334-1341

[3] Response and acquired resistance to crizotinib in Chinese patients with lung adenocarcinomas harboring MET Exon 14 splicing alternations [J].

Dong, Hua-Jie ;

Li, Peng ;

Wu, Chang-Ling ;

Zhou, Xiao-Yue ;

Lu, Hong-Jun ;

Zhou, Tong .

LUNG CANCER, 2016, 102 :118-121

[4] Acquired Resistance to Crizotinib in NSCLC with MET Exon 14 Skipping [J].

Heist, Rebecca S. ;

Sequist, Lecia V. ;

Borger, Darrell ;

Gainor, Justin F. ;

Arellano, Ronald S. ;

Le, Long P. ;

Dias-Santagata, Dora ;

Clark, Jeffrey W. ;

Engelman, Jeffrey A. ;

Shaw, Alice T. ;

Lafrate, A. John .

JOURNAL OF THORACIC ONCOLOGY, 2016, 11 (08) :1242-1245

[5] Development of efficient docking strategies and structure-activity relationship study of the c-Met type II inhibitors [J].

Li, Ming-Jing ;

Wu, Guan-Zhao ;

Kaas, Quentin ;

Jiang, Tao ;

Yu, Ri-Lei .

JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2017, 75 :241-249

[6]

Schrock Alexa B, 2017, J Thorac Oncol, V12, pe89, DOI 10.1016/j.jtho.2017.02.017

[7] A Drug Resistance Screen Using a Selective MET Inhibitor Reveals a Spectrum of Mutations That Partially Overlap with Activating Mutations Found in Cancer Patients [J].

Tiedt, Ralph ;

Degenkolbe, Elisa ;

Furet, Pascal ;

Appleton, Brent A. ;

Wagner, Sabrina ;

Schoepfer, Joseph ;

Buck, Emily ;

Ruddy, David A. ;

Monahan, John E. ;

Jones, Michael D. ;

Blank, Jutta ;

Haasen, Dorothea ;

Drueckes, Peter ;

Wartmann, Markus ;

McCarthy, Clive ;

Sellers, William R. ;

Hofmann, Francesco .

CANCER RESEARCH, 2011, 71 (15) :5255-5264

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