Highly Enantioselective Cross-Electrophile Aryl-Alkenylation of Unactivated Alkenes

被引：183

作者：

Tian, Zhi-Xiong ^{[1
]}

Qiao, Jin-Bao ^{[1
]}

Xu, Guang-Li ^{[1
]}

Pang, Xiaobo ^{[1
]}

Qi, Liangliang ^{[1
]}

Ma, Wei-Yuan ^{[1
]}

Zhao, Zhen-Zhen ^{[1
]}

Duan, Jicheng ^{[1
]}

Du, Yun-Fei ^{[1
]}

Su, Peifeng ^{[1
]}

Liu, Xue-Yuan ^{[1
]}

Shu, Xing-Zhong ^{[1
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, SKLAOC, 222 South Tianshui Rd, Lanzhou 730000, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2019年 / 141卷 / 18期

基金：

中国国家自然科学基金;

关键词：

PALLADIUM-CATALYZED 1,4-DIFUNCTIONALIZATION; COUPLING REACTIONS; REDUCTIVE DICARBOFUNCTIONALIZATION; NICKEL; HALIDES; DIFUNCTIONALIZATION; CONSTRUCTION; CYCLIZATION; ALKYLATION; ALLYLATION;

D O I：

10.1021/jacs.9b03863

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enantioselective cross-electrophile reactions remain a challenging subject in metal catalysis, and with respect to data, studies have mainly focused on stereoconvergent reactions of racemic alkyl electrophiles. Here, we report an enantioselective cross-electrophile aryl-alkenylation reaction of unactivated alkenes. This method provides access to a number of biologically important chiral molecules such as dihydrobenzofurans, indolines, and indanes. The incorporated alkenyl group is suitable for further reactions that can lead to an increase under mild conditions at room temperature, and an easily accessible chiral pyrox ligand is used to afford products with high enantioselectivity. The synthetic utility of this method is demonstrated by enabling the modification of complex molecules such as peptides, indometacin, and steroids.

引用

页码：7637 / 7643

页数：7

共 80 条

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