Effect of saponins of Panax notoginseng on synaptosomal Ca-45 uptake

被引：0

作者：

Ma, LY ^{[1
]}

Xiao, PG ^{[1
]}

Liang, FQ ^{[1
]}

Chi, MG ^{[1
]}

Dong, SJ ^{[1
]}

机构：

[1] ACAD MIL MED SCI, INST PHARMACOL & TOXICOL, BEIJING 100850, PEOPLES R CHINA

来源：

ACTA PHARMACOLOGICA SINICA | 1997年 / 18卷 / 03期

关键词：

ginseng; saponins; synaptosomes; calcium radioisotopes; nimodipine;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

AIM: To explore the calcium uptake antagonism of saponins of Panax notoginseng (PNS). METHODS: Synaptosomes were prepared from rat cerebral cortex by using differential Ficoll gradients. The effects of PNS on synaptosomal Ca-45 uptake were measured in vitro or after acute treatment. RESULTS: PNS 50 - 800 mg.L-1 produced a concentration-rated inhibition of Ca2+ uptake [IC50 = 111 (46 - 176) mg.L-1]. Both initial and maximal uptake were inhibited. Similar effect was obtained after acute PNS treatment with 200 mg.kg(-1) ip. The blocking effect of PNS was reversed by calcium in media. CONCLUSION: PNS is a calcium channel blocker in neurons.

引用

页码：213 / 215

页数：3