Synthesis of Novel Aryl and Heteroaryl Acyl Sulfonimidamides via Pd-Catalyzed Carbonylation Using a Nongaseous Precursor

被引：46

作者：

Borhade, Sanjay R. ^{[1
]}

Sandstrom, Anja ^{[1
]}

Arvidsson, Per I. ^{[1
]}

机构：

[1] Uppsala Univ, Dept Med Chem BMC, SE-75123 Uppsala, Sweden

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 05期

关键词：

PROTEASE INHIBITORS; EX-SITU; BIOISOSTERES; SULFONAMIDES; ARYLATION;

D O I：

10.1021/ol400049m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hitherto unexplored aryl and heteroaryl acyl sulfonimidamides have been prepared through the development of a new Pd-catalyzed carbonylation protocol. This novel methodology, employing sulfonimidamides as nucleophiles and CO gas ex situ released from solid Mo(CO)(6) in a sealed two-chamber system, yields a wide range of carbamate protected acyl sulfonimidamides in good to excellent yields.

引用

页码：1056 / 1059

页数：4

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