Taurine prevented cell cycle arrest and restored neurotrophic gene expression in arsenite-treated SH-SY5Y cells

被引：18
作者：
Chou, Chien-Te [1 ]
Lin, Wen-Feng [1 ]
Kong, Zwe-Ling [1 ]
Chen, Shiow-Yi [2 ]
Hwang, Deng-Fwu [1 ,3 ,4 ]
机构：
[1] Natl Taiwan Ocean Univ, Dept Food Sci, Keelung 202, Taiwan
[2] Natl Taiwan Ocean Univ, Inst Biosci & Biotechnol, Keelung, Taiwan
[3] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung, Taiwan
[4] Natl Taiwan Ocean Univ, Ctr Excellence Marine Bioenvironm & Biotechnol, Keelung, Taiwan
来源：
AMINO ACIDS | 2013年 / 45卷 / 04期
关键词：
Arsenite; Taurine; NDRG-4; BDNF; SIRT-1; Neurotrophic; INDUCED APOPTOSIS; ACTIVATION; FAMILY; BRAIN; NDRG4; SIRT1; BDNF;
D O I：
10.1007/s00726-013-1524-y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The study investigated the effect of taurine on cell viability and neurotrophic gene expression in arsenite-treated human neuroblastoma SH-SY5Y cells. Arsenite-induced intracellular reactive oxygen species (ROS) and interrupted cell cycle in SH-SY5Y cells. In addition, arsenite reduced mitochondria membrane potential (MMP) and decreased neurotrophic gene expressions such as n-myc downstream-regulated gene 4 (NDRG-4), brain-derived neurotrophic factor (BDNF) and sirtuin-1 (SIRT-1) in SH-SY5Y cells. In parallel, taurine prevented cell cycle, restored MMP and reduced the intracellular ROS level, and taurine recovered NDRG-4, BDNF and SIRT-1 gene expressions in arsenite-treated SH-SY5Y cells while taurine alone has no effect on these parameters.
引用
收藏
页码：811 / 819
页数：9
相关论文
共 31 条
  • [1] BDNF is essential to promote persistence of long-term memory storage
    Bekinschtein, Pedro
    Cammarota, Martin
    Katche, Cynthia
    Slipczuk, Leandro
    Rossato, Janine I.
    Goldin, Andrea
    Lzquierdo, Ivan
    Medina, Jorge H.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (07) : 2711 - 2716
  • [2] BOLLAWILSON K, 1987, J OCCUP ENVIRON MED, V29, P500
  • [3] Expression and regulation of NDRG2 (N-myc downstream regulated gene 2) during the differentiation of dendritic cells
    Choi, SC
    Kim, KD
    Kim, JT
    Kim, JW
    Yoon, DY
    Choe, YK
    Chang, YS
    Paik, SG
    Lim, JS
    [J]. FEBS LETTERS, 2003, 553 (03) : 413 - 418
  • [4] Arsenic-induced oxidative cerebral disorders: Protection by taurine
    Das, Joydeep
    Ghosh, Jyotirmoy
    Manna, Prasenjit
    Sinha, Mahua
    Sil, Parames C.
    [J]. DRUG AND CHEMICAL TOXICOLOGY, 2009, 32 (02) : 93 - 102
  • [5] The use of taurine analogues to investigate taurine functions and their potential therapeutic applications
    Della Corte, L
    Crichton, RR
    Duburs, G
    Nolan, K
    Tipton, KF
    Tirzitis, G
    Ward, RJ
    [J]. AMINO ACIDS, 2002, 23 (04) : 367 - 379
  • [6] RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10 (Retracted article. See vol. 158, pg. 959, 2014)
    Donmez, Gizem
    Wang, Diana
    Cohen, Dena E.
    Guarente, Leonard
    [J]. CELL, 2010, 142 (02) : 320 - 332
  • [7] El Idrissi A, 1999, J NEUROSCI, V19, P9459
  • [8] FUKUDA K, 1982, CLIN CHEM, V28, P1758
  • [9] The environmental toxin arsenite induces tau hyperphosphorylation
    Giasson, BI
    Sampathu, DM
    Wilson, CA
    Vogelsberg-Ragaglia, V
    Mushynski, WE
    Lee, VMY
    [J]. BIOCHEMISTRY, 2002, 41 (51) : 15376 - 15387
  • [10] The Effect of Taurine on Hepatic Steatosis Induced by Thioacetamide in Zebrafish (Danio rerio)
    Hammes, Thais Ortiz
    Pedroso, Gabriela Lima
    Hartmann, Carolina Rigatti
    Escobar, Thayssa Dalla Costa
    Fracasso, Laisa Beduschi
    da Rosa, Darlan Pase
    Marroni, Norma Possa
    Porawski, Marilene
    da Silveira, Themis Reverbel
    [J]. DIGESTIVE DISEASES AND SCIENCES, 2012, 57 (03) : 675 - 682
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