Association between non-alcoholic fatty liver disease and subclinical coronary atherosclerosis: An observational cohort study

被引：118

作者：

Lee, Seung Bum ^{[1
]}

Park, Gyung-Min ^{[1
]}

Lee, Jong-Young ^{[2
]}

Lee, Byung Uk ^{[1
]}

Park, Jae Ho ^{[1
]}

Kim, Byung Gyu ^{[1
]}

Jung, Seok Won ^{[1
]}

Du Jeong, In ^{[1
]}

Bang, Sung-Jo ^{[1
]}

Shin, Jung Woo ^{[1
]}

Park, Neung Hwa ^{[1
]}

Yang, Dong Hyun ^{[3
]}

Kang, Joon-Won ^{[3
]}

Lim, Tae-Hwan ^{[3
]}

Kim, Hong-Kyu ^{[4
]}

Choe, Jaewon ^{[4
]}

Lee, Han Chu ^{[5
]}

机构：

[1] Univ Ulsan, Coll Med, Ulsan Univ Hosp, Dept Internal Med, 877 Bangeojinsunhwando Ro, Ulsan 44033, South Korea

[2] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Sch Med, Dept Internal Med, 29 Saemunan Ro, Seoul 03181, South Korea

[3] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Radiol, Seoul, South Korea

[4] Univ Ulsan, Coll Med, Asan Med Ctr, Hlth Screening & Promot Ctr, Seoul, South Korea

[5] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Internal Med, Seoul, South Korea

来源：

JOURNAL OF HEPATOLOGY | 2018年 / 68卷 / 05期

关键词：

Non-alcoholic fatty liver disease; Coronary artery disease; Atherosclerosis; Coronary computed tomography angiography; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; ARTERY CALCIUM SCORE; CARDIOVASCULAR-DISEASE; PLAQUE CHARACTERISTICS; HEPATIC STEATOSIS; RISK; ACCURACY; STENOSIS; BURDEN; NAFLD;

D O I：

10.1016/j.jhep.2017.12.012

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background & Aims: There are limited data on the association between non-alcoholic fatty liver disease (NAFLD) and subclinical coronary atherosclerosis. This study investigated the influence of NAFLD on subclinical coronary atherosclerosis as detected by coronary computed tomography angiography (CCTA) in an asymptomatic population. Methods: A total of 5,121 consecutive asymptomatic individuals with no prior history of coronary artery disease or significant alcohol intake voluntarily underwent abdominal ultrasonography and CCTA as part of a general health examination. Fatty liver was assessed by ultrasonography examination. The fatty liver index and NAFLD fibrosis score were also calculated. Coronary atherosclerotic plaques on CCTA were evaluated. The association between NAFLD and subclinical coronary atherosclerosis was determined by logistic regression analysis. Results: Of the study participants, 1,979 (38.6%) had ultrasonography-diagnosed NAFLD. After adjustment for cardiovascular risk factors, there were no statistically significant differences in the adjusted odds ratios of NAFLD for calcified plaque (1.03; 95% CI 0.89-1.20; p = 0.673) and mixed plaque (1.15; 95% CI 0.93-1.42; p = 0.214). However, adjusted odds ratios for any atherosclerotic plaque (1.18; 95% CI 1.03-1.35; p = 0.016) and non-calcified plaque (1.27; 95% CI 1.08-1.48; p = 0.003) were significantly higher in NAFLD. In addition, there was a significant association of fatty liver index >= 30 with non-calcified plaque (1.37; 95% CI 1.14-1.65; p = 0.001) and NAFLD fibrosis score >=-1.455 with non-calcified plaque (1.20; 95% CI 1.08-1.42; p = 0.030). Conclusions: In this large cross-sectional study of asymptomatic individuals undergoing CCTA, NAFLD was consistently associated with non-calcified plaque, suggesting an increased cardiovascular risk. (C) 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

引用

页码：1018 / 1024

页数：7

共 34 条

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