Recurrent Giant Cell Fibroblastoma in an Infant: A Diagnostic Challenge

被引：4

作者：

Maity, Priyanka ^{[1
]}

Chatterjee, Uttara ^{[1
]}

Das, Mou ^{[1
]}

Patra, Sabita ^{[1
]}

机构：

[1] Inst Postgrad Med Educ & Res, Dept Pathol, Kolkata, India

来源：

FETAL AND PEDIATRIC PATHOLOGY | 2022年 / 41卷 / 01期

关键词：

giant cell fibroblastoma; childhood dermatofibrosarcoma protuberans; CD; 34; FNAC; RHABDOMYOSARCOMA;

D O I：

10.1080/15513815.2020.1775733

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Background:Giant cell fibroblastoma (GCF) shows a wide spectrum of morphological patterns which may lead to a misdiagnosis of sarcoma.Case Report:This 14- month- old baby was referred to us for recurrent left scrotal embryonal rhabdomyosarcoma (ERMS), first diagnosed at 8 months, status post chemotherapy. Review of previous histology, cytology (with frequent multinucleated floret type giant cells but without cross striations) and immunohistochemistry resulted in the change of diagnosis to GCF. It was re-excised, recurred at 20 months of age, and was again re-excised. The morphology was the same in both recurrences as the original.Conclusion:Despite chemotherapy, the histology of multiple recurrences for GCF remained the same as the original. Cytologically, identification of the multinucleated floret like giant cells without cross striations was helpful in differentiating this lesion from embryonal rhabdomyosarcoma.

引用

页码：171 / 178

页数：8

共 15 条

[11]

SHMOOKLER BM, 1989, CANCER-AM CANCER SOC, V64, P2154, DOI 10.1002/1097-0142(19891115)64:10<2154::AID-CNCR2820641030>3.0.CO

[12]

2-N

[13]

SHMOOKLER BM, 1982, LAB INVEST, V46, pA76

[14]

Sjöblom T, 2001, CANCER RES, V61, P5778

[15] Rhabdomyosarcoma, Spindle Cell/Sclerosing Variant: A Clinical and Histopathological Examination of this Rare Variant with Three New Cases from the Oral Cavity [J].

Smith M.H. ;

Atherton D. ;

Reith J.D. ;

Islam N.M. ;

Bhattacharyya I. ;

Cohen D.M. .

Head and Neck Pathology, 2017, 11 (4) :494-500

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