Preparation of Benzo[c]carbazol-6-amines via Manganese-Catalyzed Enaminylation of 1-(Pyrimidin-2-yI)-1H-indoles with Ketenimines and Subsequent Oxidative Cyclization

被引：35

作者：

Zhou, Xiaorong ^{[1
]}

Li, Zhenmin ^{[1
]}

Zhang, Zhiyin ^{[1
]}

Lu, Ping ^{[1
]}

Wang, Yanguang ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 05期

基金：

中国国家自然科学基金;

关键词：

C-H ACTIVATION; ACTIVE CARBAZOLE ALKALOIDS; N-METHOXYBENZAMIDES; BOND ACTIVATION; FUNCTIONALIZATION; ALKENYLATION; ANNULATIONS; INDOLES; ALKYNES; ESTERS;

D O I：

10.1021/acs.orglett.8b00204

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Manganese-catalyzed C-2-H enaminylation of 1-(pyrimidin-2-y1)-1H-indoles with ketenimines is reported. The reaction provided 2-enaminylated indole derivatives in moderate to excellent yields with a broad substrate scope. A migration of the directing group pyrimidinyl occurred during this process. The synthesized 2-enaminyl indoles could be conveniently converted into 5-ary1-7H-benzo[c]carbazol-6-amines.

引用

页码：1426 / 1429

页数：4

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