Efficient synthesis of aryl hydrazines using copper-catalyzed cross-coupling of aryl halides with hydrazine in PEG-400

被引：23

作者：

Chen, Junmin ^{[1
]}

Zhang, Yimin ^{[1
]}

Hao, Wenyan ^{[1
]}

Zhang, Rongli ^{[1
]}

Yi, Fei ^{[1
]}

机构：

[1] Jiangxi Normal Univ, Dept Chem, Nanchang 330022, Peoples R China

来源：

TETRAHEDRON | 2013年 / 69卷 / 02期

关键词：

Copper; Cross-coupling; Hydrazines; Aryl halides; PEG-400; INDOLES; AMINES;

D O I：

10.1016/j.tet.2012.11.014

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and convenient method for the synthesis of aryl hydrazines is described via copper-catalyzed cross-coupling of aryl halides with aqueous hydrazine in PEG-400. This protocol is applicable to both electron-deficient and electron-rich aryl iodides and bromides, and even to sterically hindered substrates, giving aryl hydrazines in good to excellent yields. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：613 / 617

页数：5

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