DNA analogues: From supramolecular principles to biological properties

被引：223
作者：
Leumann, CJ [1 ]
机构：
[1] Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2002年 / 10卷 / 04期
关键词：
D O I：
10.1016/S0968-0896(01)00348-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mainly driven by the needs of antisense research, a large number of of oligonucleotide analogues have been prepared and evaluated over the last 15 years. Besides minor structural modifications of the building blocks of DNA and RNA itself, a considerable effort has been devoted to the de novo design of nucleoside analogues with improved binding properties. A paticularly successful concept turned out to be that of conformational restriction. This review focuses on recent advances in this area and tries to summarize scope and limitations of this design principle. (C) 2002 Elsevier Science Ltd. All rights reserved.
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页码：841 / 854
页数：14
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