P2 Receptors for Extracellular Nucleotides in the Central Nervous System: Role of P2X7 and P2Y2 Receptor Interactions in Neuroinflammation

被引：68
|
作者：
Weisman, Gary A. [1 ,2 ,3 ]
Camden, Jean M. [1 ,3 ]
Peterson, Troy S. [2 ,3 ]
Ajit, Deepa [1 ,3 ]
Woods, Lucas T. [1 ,3 ]
Erb, Laurie [1 ,3 ]
机构：
[1] Univ Missouri, Dept Biochem, Life Sci Ctr 540E, Columbia, MO 65211 USA
[2] Univ Missouri, Interdisciplinary Neurosci Program, Columbia, MO 65211 USA
[3] Univ Missouri, Christopher S Bond Life Sci Ctr, Columbia, MO 65211 USA
来源：
MOLECULAR NEUROBIOLOGY | 2012年 / 46卷 / 01期
关键词：
P2Y(2) receptor; P2X7; receptor; Neuroprotection; Neuroinflammation; AMYLOID-BETA-PEPTIDE; GROWTH-FACTOR RECEPTOR; TUMOR-NECROSIS-FACTOR; DORSAL-ROOT GANGLION; NONADRENERGIC INHIBITORY NERVES; TRANSFORMED MOUSE FIBROBLASTS; PURINERGIC P2X(7) RECEPTOR; PROTEIN-COUPLED RECEPTOR; MESSENGER-RNA EXPRESSION; FOCAL TYROSINE KINASE;
D O I：
10.1007/s12035-012-8263-z
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Extracellular nucleotides induce cellular responses in the central nervous system (CNS) through the activation of ionotropic P2X and metabotropic P2Y nucleotide receptors. Activation of these receptors regulates a wide range of physiological and pathological processes. In this review, we present an overview of the current literature regarding P2X and P2Y receptors in the CNS with a focus on the contribution of P2X7 and P2Y(2) receptor-mediated responses to neuroinflammatory and neuroprotective mechanisms.
引用
收藏
页码：96 / 113
页数：18
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