Access to β-Hydroxyl Esters via Copper-Catalyzed Reformatsky Reaction of Ketones and Aldehydes

被引：2

作者：

Ouyang, Lu ^{[1
]}

Liao, Jian Hua ^{[1
]}

Xia, Yan Ping ^{[1
]}

Luo, Ren Shi ^{[1
]}

机构：

[1] Gannan Med Univ, Sch Pharm, Ganzhou 341000, Jiangxi, Peoples R China

来源：

SYNLETT | 2020年 / 31卷 / 14期

基金：

中国国家自然科学基金;

关键词：

Reformatsky reaction; copper catalysis; ketones; beta-hydroxyl esters; manganese powder; BROMODIFLUOROMETHYL KETONE; REAGENTS; TITANIUM;

D O I：

10.1055/s-0040-1707110

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and simple Cu-catalyzed Reformatsky reaction of ketones and aldehydes has been accomplished with ethyl iodoacetate. Excellent yields of beta-hydroxyl esters were achieved with a range of ketones and aldehydes, which varied from aromatic to aliphatic, unsaturated to saturated ketones and aldehydes. This practical and convenient transformation was conducted with inexpensive, readily available, and commercial starting materials under mild reaction conditions.

引用

页码：1418 / 1422

页数：5

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