Seminal plasma glycoproteins in male infertility and prostate diseases: is there a chance for glyco-biomarkers?

被引：25

作者：

Ferens-Sieczkowska, Miroslawa ^{[1
]}

Kowalska, Beata ^{[1
]}

Kratz, Ewa Maria ^{[1
]}

机构：

[1] Wroclaw Med Univ, Dept Chem & Immunochem, PL-50345 Wroclaw, Poland

来源：

BIOMARKERS | 2013年 / 18卷 / 01期

关键词：

alpha 1-acid glycoprotein; fibronectin; glycodelin-S; glycome; prostate-specific antigen; ALPHA(1)-ACID GLYCOPROTEIN; ALPHA-1-ACID GLYCOPROTEIN; ALTERED GLYCOSYLATION; GELATIN-BINDING; SIALIC-ACID; CARBOHYDRATE STRUCTURE; PROTEOMIC APPROACH; ANTIGEN ISOFORMS; OVARIAN-CANCER; SEMEN ANALYSIS;

D O I：

10.3109/1354750X.2012.719035

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Context: Disturbed protein-carbohydrate interactions may underlie the molecular mechanism of some diseases of the male reproductive tract, including infertility and prostate diseases. Objective: To summarize the current knowledge on the glycosylation patterns of glycodelin-S, fibronectin, prostate-specific antigen, and alpha(1)-acid glycoprotein. Results: Some rare glycoepitopes have been found in seminal plasma glycoproteins: high-mannose and polylactosamine-type glycans, and N-glycans containing N-acetyl-galactosamine. The glycosylation profiles occur altered in pathological conditions. Conclusion: Further detailed studies may lead up to indicate the biomarkers useful in the management of male reproductive tract disorders.

引用

页码：10 / 22

页数：13

共 123 条

[1] Glyco-biomarkers: Potential determinants of cellular physiology and pathology [J].

Alavi, Azita ;

Axford, John S. .

DISEASE MARKERS, 2008, 25 (4-5) :193-205

[2]

ARMBRUSTER DA, 1993, CLIN CHEM, V39, P181

[3] Evaluation of the serum N-linked glycome for the diagnosis of cancer and chronic inflammation [J].

Arnold, James N. ;

Saldova, Radka ;

Hamid, Umi M. Abd ;

Rudd, Pauline M. .

PROTEOMICS, 2008, 8 (16) :3284-3293

[4] Seminal fibronectin in fertile and infertile males [J].

Attia, A. M. ;

Hassan, A. ;

Zalata, A. ;

Hagag, M. ;

Yousef, K. E. ;

Mostafa, T. .

ANDROLOGIA, 2011, 43 (06) :387-391

[5] Diagnostic tools in male infertility-the question of sperm dysfunction [J].

Barratt, Christopher L. R. ;

Mansell, Steven ;

Beaton, Catherine ;

Tardif, Steve ;

Oxenham, Senga K. .

ASIAN JOURNAL OF ANDROLOGY, 2011, 13 (01) :53-58

[6] Proteomic Analysis of Seminal Plasma from Normal Volunteers and Post-Vasectomy Patients Identifies over 2000 Proteins and Candidate Biomarkers of the Urogenital System [J].

Batruch, Ihor ;

Lecker, Irene ;

Kagedan, Daniel ;

Smith, Christopher R. ;

Mullen, Brendan J. ;

Grober, Ethan ;

Lo, Kirk C. ;

Diamandis, Eleftherios P. ;

Jarvi, Keith A. .

JOURNAL OF PROTEOME RESEARCH, 2011, 10 (03) :941-953

[7] MOLECULAR-MASS AND CARBOHYDRATE STRUCTURE OF PROSTATE-SPECIFIC ANTIGEN - STUDIES FOR ESTABLISHMENT OF AN INTERNATIONAL PSA STANDARD [J].

BELANGER, A ;

VANHALBEEK, H ;

GRAVES, HCB ;

GRANDBOIS, K ;

STAMEY, TA ;

HUANG, LH ;

POPPE, I ;

LABRIE, F .

PROSTATE, 1995, 27 (04) :187-197

[8] MEASUREMENT OF PROSTATE-SPECIFIC ANTIGEN IN SERUM AS A SCREENING-TEST FOR PROSTATE-CANCER [J].

CATALONA, WJ ;

SMITH, DS ;

RATLIFF, TL ;

DODDS, KM ;

COPLEN, DE ;

YUAN, JJJ ;

PETROS, JA ;

ANDRIOLE, GL .

NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (17) :1156-1161

[9] The acute phase protein α1-acid glycoprotein:: A model for altered glycosylation during diseases [J].

Ceciliani, Fabrizio ;

Pocacqua, Vanessa .

CURRENT PROTEIN & PEPTIDE SCIENCE, 2007, 8 (01) :91-108

[10] Glycodelin-S in human seminal plasma reduces cholesterol efflux and inhibits capacitation of spermatozoa [J].

Chiu, PCN ;

Chung, MK ;

Tsang, HY ;

Koistinen, R ;

Koistinen, H ;

Seppala, M ;

Lee, KF ;

Yeung, WSB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (27) :25580-25589

← 1 2 3 4 5 6 7 8 9 10 →