Autoregulation of AbsB (RNase III) expression in Streptomyces coelicolor by endoribonucleolytic cleavage of absB operon transcripts

被引：21

作者：

Xu, Weijing ^{[1
]}

Huang, Jianqiang ^{[1
]}

Cohen, Stanley N. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA

来源：

JOURNAL OF BACTERIOLOGY | 2008年 / 190卷 / 15期

关键词：

D O I：

10.1128/JB.00558-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Streptomyces coelicolor absB gene encodes an RNase III family endoribonuclease and is normally essential for antibiotic biosynthesis. Here we report that AbsB controls its own expression by sequentially and site specifically cleaving stem-loop segments of its polycistronic transcript. Our results demonstrate a ribonucleolytic regulatory role for AbsB in vivo.

引用

页码：5526 / 5530

页数：5

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