Using magnetic core-shell nanoparticles coated with an ionic liquid dispersion assisted by effervescence powder for the micro-solid-phase extraction of four beta blockers from human plasma by ultra high performance liquid chromatography with mass spectrometry detection

被引:30
作者
Jamshidi, Sara [1 ,2 ]
Rofouei, Mohammad Kazem [2 ]
Thorsen, Gunnar [1 ,3 ]
机构
[1] Stockholm Univ, Dept Environm Sci & Analyt Chem ACES, Stockholm, Sweden
[2] Kharazmi Univ, Fac Chem, Tehran, Iran
[3] IVL Swedish Environm Res Inst, Stockholm, Sweden
关键词
beta blockers; effervescent powders; ionic liquids; liquid chromatography; magnetic nanoparticles; GRAPHENE OXIDE; MICROEXTRACTION; HPLC; PROPRANOLOL; BEHAVIOR; REMOVAL; GEL;
D O I
10.1002/jssc.201800834
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
In this work, a novel, efficient, and green sorbent, SiO2@Fe3O4 has been created and functionalized with 1-butyl-3-methylimidazolium hexafluorophosphate as an ionic liquid. This sorbent was applied for microextraction of four beta blockers, propranolol, metoprolol, atenolol, and alprenolol with bupivacaine as internal standard from human plasma followed by liquid chromatography with mass spectrometric detection. A mixture of sodium bicarbonate and sodium dihydrogen phosphate was used as an extractant dispersive agent (effervescent power) to enhance the interaction between the magnetic sorbent and analytes. Main affecting parameters on microextraction and elution were optimized. Figures of merit for dispersive solid phase extraction with ionic liquid coated magnetic nanoparticles assisted by effervescent powder were calculated under the optimized conditions. The detection limits for propranolol, metoprolol, atenolol, and alprenolol were found at 0.33, 0.62, 0.03, and 0.44 ng/mL, respectively. For all analytes, good linearity was obtained. Intra-(n = 5) and interday (n = 10) precision were both under 6.3% while the preconcentration factors were obtained in the range between 15-18. The extraction efficiencies for each analyte ranged from 75 to 91%. The method was successfully applied for determination of trace amounts of the beta blockers in human plasma samples.
引用
收藏
页码:698 / 705
页数:8
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