Assessing evolutionary risks of resistance for new antimicrobial therapies

被引：35

作者：

Brockhurst, Michael A. ^{[1
]}

Harrison, Freya ^{[2
]}

Veening, Jan-Willem ^{[3
]}

Harrison, Ellie ^{[1
]}

Blackwell, Grace ^{[4
]}

Iqbal, Zamin ^{[4
]}

Maclean, Craig ^{[5
]}

机构：

[1] Univ Sheffield, Dept Anim & Plant Sci, Western Bank, Sheffield, S Yorkshire, England

[2] Univ Warwick, Sch Life Sci, Gibbet Hill Campus, Coventry, W Midlands, England

[3] Univ Lausanne, Fac Biol & Med, Dept Fundamental Microbiol, Lausanne, Switzerland

[4] EMBL EBI, Wellcome Genome Campus, Hinxton, England

[5] Univ Oxford, Dept Zool, Oxford, England

来源：

NATURE ECOLOGY & EVOLUTION | 2019年 / 3卷 / 04期

基金：

英国生物技术与生命科学研究理事会;

关键词：

ANTIBIOTIC-RESISTANCE; PSEUDOMONAS-AERUGINOSA; FUNCTIONAL METAGENOMICS; FITNESS COSTS; DIAGNOSIS; SELECTION; CULTURE; MODEL;

D O I：

10.1038/s41559-019-0854-x

中图分类号：

Q14 [生态学（生物生态学）];

学科分类号：

071012 ; 0713 ;

摘要：

New antibiotics are urgently needed to combat rising rates of resistance against all existing classes of antimicrobials. We highlight key issues that complicate the prediction of resistance evolution in the real world and outline the ways in which these can be overcome.

引用

页码：515 / 517

页数：3

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