Change in Pseudomonas aeruginosa prevalence in cystic fibrosis adults over time

被引：32

作者：

Crull, Mathew R. ^{[1
,4
]}

Ramos, Kathleen J. ^{[1
]}

Caldwell, Ellen ^{[1
]}

Mayer-Hamblett, Nicole ^{[2
,3
]}

Aitken, Moira L. ^{[1
]}

Goss, Christopher H. ^{[1
,2
]}

机构：

[1] Univ Washington, Dept Med, Seattle, WA 98195 USA

[2] Univ Washington, Dept Pediat, Div Pulm, Seattle, WA 98195 USA

[3] Univ Washington, Dept Biostat, Seattle, WA 98195 USA

[4] Univ Washington, Med Ctr, Campus Box 3565221959 NE Pacific, Seattle, WA 98195 USA

来源：

BMC PULMONARY MEDICINE | 2016年 / 16卷

关键词：

Cystic fibrosis; Pseudomonas aeruginosa; Chronic infection; Epidemiology; Temporal trends; YOUNG-CHILDREN; LUNG INFECTION; RISK-FACTORS; COLONIZATION; ERADICATION; EPIDEMIOLOGY; PREDICTORS; SURVIVAL; DISEASE;

D O I：

10.1186/s12890-016-0333-y

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background: Little is known about risk factors for chronic and mucoid Pseudomonas aeruginosa (Pa) infection in cystic fibrosis (CF) adults, and whether the prevalence is changing. Methods: We employed a retrospective cohort to analyze data from a single adult CF center (2002 to 2012). Regression models were used to assess independent predictors and change in prevalence of chronic and mucoid Pa infection over time. Results: The odds ratio of mucoid Pa infection was significantly less in individuals with better baseline lung function (OR 0.84,95%CI:0.77-0.92) and those diagnosed after the age of 25 (OR 0.21, 95%CI:0.05-0.95). The prevalence of chronic Pa and mucoid Pa decreased during the time interval. After adjusting for confounders, the observed decrease in chronic and mucoid Pa between 2002 and 2012 was no longer significant. Conclusions: The prevalence of chronic and mucoid Pa is decreasing. Larger studies are needed to confirm these regional trends and their significance.

引用

页数：7

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