Metal-free artificial nucleases based on simple oxime and hydroxylamine scaffolds

被引：20
作者：
Fernandes, Luciano [1 ,2 ]
Fischer, Franciele L. [1 ,2 ]
Ribeiro, Carolina W. [1 ]
Silveira, Gustavo P. [2 ]
Sa, Marcus M. [2 ]
Nome, Faruk [2 ]
Terenzi, Hernan [1 ]
机构：
[1] Univ Fed Santa Catarina, Dept Bioquim, BR-88040900 Florianopolis, SC, Brazil
[2] Univ Fed Santa Catarina, Dept Quim, BR-88040900 Florianopolis, SC, Brazil
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 16期
关键词：
DNA cleavage; metal-free nuclease; oximes; hydroxylamines;
D O I：
10.1016/j.bmcl.2008.07.052
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Hydrolysis of DNA is of increasing importance in biotechnology and medicine. In this Letter, we present the DNA-cleavage potential of metal-free hydroxylamines and oximes as new members of nucleic acid cleavage agents. (c) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4499 / 4502
页数：4
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