Examining Phenotypic Differences in Gaze Avoidance Between Autism Spectrum Disorder and Fragile X Syndrome

被引:2
作者
Wilkinson, Ellen H. [1 ]
Britton, Tobias C. [1 ]
Hall, Scott S. [1 ,2 ]
机构
[1] Sch Med, Stanford Univ, Stanford, CA USA
[2] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Rm 1365, 401 Quarry Rd, Stanford, CA 94305 USA
来源
AJIDD-AMERICAN JOURNAL ON INTELLECTUAL AND DEVELOPMENTAL DISABILITIES | 2022年 / 127卷 / 06期
关键词
eye gaze avoidance; developmental disability; autism spectrum disorder; fragile X syndrome; ABERRANT BEHAVIOR CHECKLIST; TREATMENT END-POINT; EYE CONTACT; COOCCURRING CONDITIONS; SOCIAL GAZE; CHILDREN; MALES; ANXIETY; FMR1; BOYS;
D O I
10.1352/1944-7558-127.6.435
中图分类号
G76 [特殊教育];
学科分类号
040109 ;
摘要
We examined potential phenotypic differences in eye gaze avoidance exhibited by boys with autism spectrum disorder (ASD) and boys with fragile X syndrome (FXS). In Study 1, the Eye Contact Avoidance Scale (ECAS) was administered to caregivers of boys aged 7-18 years with FXS (n = 148), ASD (n = 168), and mixed developmental disabilities (MDD; n = 128). In Study 2, subsets of boys with FXS (n = 31) and boys with ASD (n = 25) received a brief behavioral treatment probe to improve eye contact. Results showed that boys with FXS obtained significantly higher scores on the ECAS compared to boys with ASD and MDD. Exposure to the brief behavioral treatment probe resulted in significant decreases in scores for boys with FXS, but not for boys with ASD.
引用
收藏
页码:435 / 454
页数:20
相关论文
共 85 条
[1]   The fragile X syndrome-autism comorbidity: what do we really know? [J].
Abbeduto, Leonard ;
McDuffie, Andrea ;
Thurman, Angela John .
FRONTIERS IN GENETICS, 2014, 5
[2]  
AMAN MG, 1985, AM J MENT DEF, V89, P485
[3]  
American Psychiatric Association, 2013, DIAGNOSTIC STAT MANU, DOI 10.1176/appi.books.9780890425596
[4]   Measuring social communication behaviors as a treatment endpoint in individuals with autism spectrum disorder [J].
Anagnostou, Evdokia ;
Jones, Nancy ;
Huerta, Marisela ;
Halladay, Alycia K. ;
Wang, Paul ;
Scahill, Lawrence ;
Horrigan, Joseph P. ;
Kasari, Connie ;
Lord, Cathy ;
Choi, Dennis ;
Sullivan, Katherine ;
Dawson, Geraldine .
AUTISM, 2015, 19 (05) :622-636
[5]  
[Anonymous], 2018, Morbidity and Mortality Weekly Report. Surveillance Summaries (Washington, V70, P1, DOI [DOI 10.15585/MMWR.SS6904A1, DOI 10.15585/MMWR.SS7011A1, 10.15585/mmwr.ss6904a1, DOI 10.15585/MMWR.SS7202A1]
[6]  
[Anonymous], 2008, EARLY CHILDHOOD ASSE
[7]   Co-occurring conditions associated with FMR1 gene variations:: Findings from a national parent survey [J].
Bailey, Donald B., Jr. ;
Raspa, Melissa ;
Olmsted, Murrey ;
Holiday, David B. .
AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2008, 146A (16) :2060-2069
[8]   The facilitation of social-emotional understanding and social interaction in high-functioning children with autism: Intervention outcomes [J].
Bauminger, N .
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 2002, 32 (04) :283-298
[9]   Outcome measures in intervention trials for adults with autism spectrum disorders; a systematic review of assessments of core autism features and associated emotional and behavioural problems [J].
Brugha, Traolach S. ;
Doos, Lucy ;
Tempier, Althea ;
Einfeld, Stewart ;
Howlin, Patricia .
INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH, 2015, 24 (02) :99-115
[10]   Joint attention and children with autism: A review of the literature [J].
Bruinsma, Y ;
Koegel, RL ;
Koegel, LK .
MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS, 2004, 10 (03) :169-175