The paracellular component of water flow in the rat submandibular salivary gland

被引:0
作者
Murakami, M
Shachar-Hill, B
Steward, MC
Hill, AE
机构
[1] Univ Cambridge, Physiol Lab, Cambridge CB2 3EG, England
[2] Natl Inst Physiol Sci, Dept Mol Physiol, Okazaki, Aichi 444, Japan
[3] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England
来源
JOURNAL OF PHYSIOLOGY-LONDON | 2001年 / 537卷 / 03期
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暂无
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
1. The pathway of water flow during salivary secretion by the isolated, perfused rat submandibular gland was examined using a family of homologous radiodextran molecules as probes of paracellular fluid transfer. 2. The secretion/perfusate ratio (S/P) of the secreted probes versus molecular radius during fluid secretion evoked by ACh could be resolved into two components: one that fitted a free-diffusion (Stokes-Einstein) curve and indicated diffusion through large channels, and a convective component that was linearly related to radius. 3. The convective component had a cut-off point at 0.5 nm (5 Angstrom) radius and an S/P intercept of near 1.0 at the radius of water, which indicates that most of the volume flow was paracellular. 4. The nature of such a paracellular flow is discussed together with the possible integration of this volume flow with the cellular transport of ions, resulting in an isotonic primary secretion from the gland.
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页码:899 / 906
页数:8
相关论文
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