Detailed visual assessment of striatal dopaminergic depletion in patients with idiopathic normal pressure hydrocephalus: unremarkable or not?

被引：9

作者：

Lee, Jeong-Yoon ^{[1
]}

Park, Soo Bin ^{[2
]}

Lee, Mina ^{[1
]}

Ju, Hyunjin ^{[1
]}

Im, Kayeong ^{[1
]}

Kwon, Kyum-Yil ^{[1
]}

机构：

[1] Soonchunhyang Univ, Sch Med, Dept Neurol, Seoul Hosp, 59 Daesagwan Ro, Seoul 04401, South Korea

[2] Soonchunhyang Univ, Sch Med, Dept Nucl Med, Seoul Hosp, Seoul, South Korea

来源：

BMC NEUROLOGY | 2020年 / 20卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Dopamine transporter imaging; FP-CIT PET; Normal pressure hydrocephalus; Striatal dopamine; PARKINSONISM; SPECT; PERFUSION; SYMPTOMS; DISEASE; PET;

D O I：

10.1186/s12883-020-01861-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background Dopamine transporter (DAT) imaging may enable clinicians to discriminate idiopathic normal pressure hydrocephalus (iNPH) from other parkinsonian disorders. However, a specific pattern of dopaminergic loss in DAT imaging of iNPH patients remains to be further elucidated. Methods In this preliminary study, 11 patients with iNPH in our hospital between March 2017 and February 2019 were finally enrolled. A diagnosis of iNPH was made according to the two established criteria. For visual analysis of DAT imaging, a striatum was divided into five domains. A semi-quantitative visual assessment was performed with a consensus between a nuclear medicine specialist and an experienced neurologist who were blinded to the clinical diagnosis. Results Striatal dopaminergic deficits were abnormal in 90.9% (10/11) of patients with iNPH. The degree of dopaminergic reduction was mild and heterogeneous. However, a tendency of preferential striatal DAT loss in the caudate nucleus (90.9%, 10/11) than in the putamen (72.7%, 8/11) was observed, whereas ventral portion (9.1%, 1/11) was relatively preserved. Conclusion Striatal dopaminergic depletion might be mild and heterogeneous in patients with iNPH. These dopaminergic deficits were more common in the caudate nucleus than in the putamen, suggesting a pattern different from other degenerative parkinsonian disorders.

引用

页数：7