Mitochondrial targeting of growth suppressor protein DLC2 through the START domain

被引：24

作者：

Ng, DCH

Chan, SF

Kok, KH

Yam, JWP

Ching, YP

Ng, IOL

Jin, DY ^{[1
]}

机构：

[1] Univ Hong Kong, Dept Biochem, Fac Med, Hong Kong, Hong Kong, Peoples R China

[2] Univ Hong Kong, Dept Pathol, Fac Med, Hong Kong, Hong Kong, Peoples R China

来源：

FEBS LETTERS | 2006年 / 580卷 / 01期

关键词：

deleted in liver cancer 2; steroidogenic acute regulatory protein-related lipid transfer domain; mitochondria; lipid droplets; growth suppressor protein; hepatocellular carcinoma;

D O I：

10.1016/j.febslet.2005.11.073

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Deleted in liver cancer 2 (DLC2) is a candidate tumor suppressor frequently found to be deleted in hepatocellular carcinoma. In this study, we determined the subcellular localization of DLC2. Co-localization and biochemical fractionation studies revealed that DLC2 localized to mitochondria. In addition, the DLC2-containing cytoplasmic speckles were in proximity to lipid droplets. A DLC2 mutant containing the steroidogenic acute regulatory protein-related lipid transfer (START) domain only showed a localization pattern identical to that of DLC2. Taken together, we have provided the first evidence for mitochondrial localization of DLC2 through the START domain. These findings might have implications in liver physiology and carcinogenesis. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：191 / 198

页数：8

共 42 条

[1] Give lipids a START: The StAR-related lipid transfer (START) domain in mammals [J].